Paraquat exposure and Parkinson's disease: A systematic review and meta-analysis

被引：60
|
作者：
Tangamornsuksan, Wimonchat [1 ,2 ]
Lohitnavy, Ornrat [1 ,2 ,3 ]
Sruamsiri, Rosarin [2 ,4 ]
Chaiyakunapruk, Nathorn [2 ,4 ,5 ,6 ,7 ]
Scholfield, C. Norman [1 ,2 ]
Reisfeld, Brad [1 ,8 ]
Lohitnavy, Manupat [1 ,2 ,3 ]
机构：
[1] Naresuan Univ, Fac Pharmaceut Sci, Ctr Excellence Environm Hlth & Toxicol, 99 M9 Nakornsawan Phitsanulok Rd, Phitsanulok 65000, Thailand
[2] Naresuan Univ, Fac Pharmaceut Sci, Dept Pharm Practice, Phitsanulok, Thailand
[3] Naresuan Univ, Fac Pharmaceut Sci, Pharmacokinet Res Unit, Phitsanulok, Thailand
[4] Naresuan Univ, Fac Pharmaceut Sci, Ctr Pharmaceut Outcomes Res, Dept Pharm Practice, Phitsanulok, Thailand
[5] Monash Univ Malaysia, Sch Pharm, Selangor, Malaysia
[6] Univ Wisconsin, Sch Pharm, Madison, WI USA
[7] Univ Queensland, Sch Populat Hlth, Brisbane, Qld, Australia
[8] Colorado State Univ, Dept Chem & Biol Engn, Ft Collins, CO 80523 USA
来源：
ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH | 2019年 / 74卷 / 05期
关键词：
Paraquat; Parkinson's disease; systematic review and meta-analysis; ENVIRONMENTAL RISK-FACTORS; PESTICIDE EXPOSURE; PUBLICATION BIAS; ALPHA-SYNUCLEIN; ANIMAL-MODELS; BRAIN; PREVALENCE; MANEB; MICE;
D O I：
10.1080/19338244.2018.1492894
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
To reconcile and unify available results regarding paraquat exposure and Parkinson's disease (PD), we conducted a systematic review and meta-analysis to provide a quantitative estimate of the risk of PD associated with paraquat exposure. Six scientific databases including PubMed, Cochrane libraries, EMBASE, Scopus, ISI Web of Knowledge, and TOXLINE were systematically searched. The overall odds ratios (ORs) with corresponding 95% CIs were calculated using a random-effects model. Of 7,309 articles identified, 13 case control studies with 3,231 patients and 4,901 controls were included into our analysis. Whereas, one prospective cohort studies was included into our systematic review. A subsequent meta-analysis showed an association between PD and paraquat exposure (odds ratio = 1.64 (95% CI: 1.27-2.13; I-2 = 24.8%). There is a statistically significant association between paraquat exposure and PD. Thus, future studies regarding paraquat and Parkinson's disease are warranted.
引用
收藏
页码：225 / 238
页数：14
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