Circadian clocks of the kidney: function, mechanism, and regulation

被引：1

作者：

Costello, Hannah M. ^{[1
,2
]}

Johnston, Jermaine G. ^{[2
,3
]}

Juffre, Alexandria ^{[1
,2
,4
]}

Crislip, G. Ryan ^{[1
,2
]}

Gumz, Michelle L. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Florida, Dept Physiol & Funct Genom, Gainesville, FL 32611 USA

[2] Univ Florida, Dept Med, Div Nephrol Hypertens & Renal Transplantat, Gainesville, FL 32611 USA

[3] Vet Affairs Med Ctr, North Florida South Georgia Malcom Randall Dept, Gainesville, FL 32608 USA

[4] Univ Florida, Dept Biochem & Mol Biol, Gainesville, FL 32611 USA

[5] Univ Florida, Ctr Integrat Cardiovasc & Metab Dis, Gainesville, FL 32611 USA

来源：

PHYSIOLOGICAL REVIEWS | 2022年 / 102卷 / 04期

关键词：

chronic kidney disease; renal; rhythm; NOCTURNAL BLOOD-PRESSURE; PROTEIN PERIOD 1; AFFINITY NA+/GLUCOSE COTRANSPORTER; EPITHELIAL SODIUM-CHANNEL; NA+/H+ EXCHANGER NHE3; GENE-EXPRESSION; RENAL-FUNCTION; DIURNAL-VARIATION; GLUCOCORTICOID-RECEPTOR; ALDOSTERONE LEVELS;

D O I：

暂无

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

An intrinsic cellular circadian clock is located in nearly every cell of the body. The peripheral circadian clocks within the cells of the kidney contribute to the regulation of a variety of renal processes. In this review, we summarize what is currently known regarding the function, mechanism, and regulation of kidney clocks. Additionally, the effect of extrarenal physiological processes, such as endocrine and neuronal signals, on kidney function is also reviewed. Circadian rhythms in renal function are an integral part of kidney physiology, underscoring the importance of considering time of day as a key biological variable. The field of circadian renal physiology is of tremendous relevance, but with limited physiological and mechanistic information on the kidney clocks this is an area in need of extensive investigation.

引用

页数：34

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