A simple, clean, straightforward, and environmentally benign one-pot, three-component reaction of various arylglyoxal monohydrates, β-naphthol, and barbituric acid [pyrimidine-2,4,6(1 H,3 H,5 H)-trione] or thiobarbituric acid in the presence of catalytic amounts potassium phthalimide- N -oxyl (PPINO), as a mild and efficient organocatalyst in aqueous media under reflux conditions is reported. This transformation produced the novel diverse-substituted 12-benzoyl-8,12-dihydro-9 H -benzo[5,6]chromeno[2,3- d ]pyrimidine-9,11(10 H)-diones and their sulfur analogues in 82-93% yield via filtration and without utilization of any chromatography. The high yields of products, very simple operation, easy workup, availability of starting materials, green process, and high atom-economy are the main benefits of this synthetic strategy. © 2020 Georg Thieme Verlag. All rights reserved.
