Drugs in Focus: Octreotide Use in Children With Gastrointestinal Disorders

被引：6

作者：

Mas, Emmanuel ^{[1
,2
]}

Borrelli, Osvaldo ^{[3
]}

Broekaert, Ilse ^{[4
,5
]}

De-Carpi, J. Martin ^{[6
]}

Dolinsek, Jernej ^{[7
]}

Miele, Erasmo ^{[8
]}

Pienar, Corina ^{[9
]}

Koninckx, C. Ribes ^{[10
]}

Thomassen, Ruth-Anne ^{[11
]}

Thomson, Mike ^{[12
]}

Tzivinikos, Christo ^{[13
]}

Benninga, Marc A. ^{[14
]}

机构：

[1] CHU Toulouse, Unite Gastroenterol Hepatol Nutr Diabetol & Malad, Hop Enfants, Toulouse, France

[2] Univ Toulouse, IRSD, INSERM, INRAE,ENVT,UPS, Toulouse, France

[3] Great Ormond St Hosp Sick Children, Neurogastroenterol & Motil Unit, Dept Paediat Gastroenterol, London, England

[4] Univ Cologne, Fac Med, Dept Paediat, Cologne, Germany

[5] Univ Cologne, Univ Hosp Cologne, Cologne, Germany

[6] Hosp St Joan de Deu, Dept Paediat Gastroenterol Hepatol & Nutr, Barcelona, Spain

[7] Univ Med Ctr Maribor, Dept Paediat, Maribor, Slovenia

[8] Univ Naples Federico II, Dept Translat Med Sci, Sect Paediat, Naples, Italy

[9] Victor Babes Univ Med & Pharm, Dept Paediat, Paediat Clin 2, Timisoara, Romania

[10] La Fe Univ Hosp, Paediat Gastroenterol, Valencia, Spain

[11] Oslo Univ Hosp, Dept Paediat Med, Div Paediat & Adolescent Med, Oslo, Norway

[12] Sheffield Childrens Hosp NHS Fdn Trust, Ctr Paediat Gastroenterol, Sheffield, S Yorkshire, England

[13] Al Jalila Childrens Specialty Hosp, Dept Paediat Gastroenterol, Dubai, U Arab Emirates

[14] Univ Amsterdam, Emma Childrens Hosp, Dept Paediat Gastroenterol & Nutr, Amsterdam UMC, Amsterdam, Netherlands

来源：

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION | 2022年 / 74卷 / 01期

关键词：

bleeding; children; chylous ascites; diarrhoea; ocreotide; somatostatin; ASPARAGINASE-ASSOCIATED PANCREATITIS; PORTAL-HYPERTENSION; PEDIATRIC-PATIENTS; CHYLOUS ASCITES; CHYLOTHORAX; THERAPY; MANAGEMENT; MOTILITY; ANGIODYSPLASIA; SOMATOSTATIN;

D O I：

10.1097/MPG.0000000000003294

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Octreotide, a somatostatin analogue, has been used for more than 20 years in children with gastrointestinal bleeding, chylothorax or chylous ascites, intestinal lymphangiectasia, pancreatitis, intestinal dysmotility, and severe diarrhoea; however, until now, there is a lack of randomised clinical trials evaluating the efficacy of this compound in childhood. Hence, we aimed to review the literature in order to determine the evidence of its use and safety in children, using PubMed from 2000 to 2021 with the search terms "octreotide" and "children" and "bleeding or chylous ascites or chylothorax or acute pancreatitis or lymphangiectasia or diarrhoea or intestinal dysmotility".

引用

页码：1 / 6

页数：6

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