Long-term lead elimination from plasma and whole blood after poisoning

被引：15
|
作者：
Rentschler, Gerda [1 ]
Broberg, K. [1 ]
Lundh, T. [1 ]
Skerfving, S. [1 ]
机构：
[1] Lund Univ, Div Occupat & Environm Med, SE-22185 Lund, Sweden
来源：
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH | 2012年 / 85卷 / 03期
关键词：
Human; Urine; Pb; Kinetics; Modelling; Risk; DEHYDRATASE POLYMORPHISM; OCCUPATIONAL EXPOSURE; WORKERS; KINETICS; CHILDREN; KIDNEY; HUMANS; SERUM; BONE; END;
D O I：
10.1007/s00420-011-0673-0
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Blood lead (B-Pb), one of the most used toxicological biomarker all kind, has serious limitations. Thus, the objective is to evaluate whether plasma lead (P-Pb) is more adequate. A long-term follow-up study of five cases of lead poisoning. P-Pb was analysed by inductively coupled plasma mass spectrometry. Kinetics after end of exposure was modelled. P-Pb at severe poisoning was about 20 mu g/L; haematological effects at about 5 mu g/L. Biological half-time of P-Pb was about 1 month; B-Pb decay was much slower. P-Pb is a valuable biomarker of exposure to and risk, particularly at high exposure.
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页码：311 / 316
页数：6
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