Importance of IL-1β in SARS-CoV-2 infection

被引：0
|
作者：
Behboudi, Emad [1 ]
Teimouri, Hossein [1 ]
Hamidi-Sofiani, Vahideh [1 ]
Memarian, Ali [2 ,3 ]
机构：
[1] Golestan Univ Med Sci, Student Res Comm, Fac Med, Dept Microbiol, Gorgan, Iran
[2] Golestan Univ Med Sci, Stem Cell Res Ctr, Gorgan, Iran
[3] Golestan Univ Med Sci, Fac Med, Dept Immunol, Gorgan, Iran
来源：
INTERNATIONAL JOURNAL OF PEDIATRICS-MASHHAD | 2022年 / 10卷 / 09期
关键词：
COVID-19; Cytokine storm; IL-1; beta; Inflammation; SARS-CoV2; NF-KAPPA-B; MACROPHAGE ACTIVATION SYNDROME; MONONUCLEAR-CELLS; CYTOKINE STORM; GASDERMIN D; INFLAMMATION; INTERLEUKIN-1-BETA; IL-1; TRANSCRIPTION; PATHOGENESIS;
D O I：
10.3390/ijms22042108.5005
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) provokes the host immune responses and induces severe respiratory syndrome by overreaction of immune cells. IL-1 beta is a proinflammatory cytokine highly associated with the related inflammation and cytokine storm, and several IL-1 beta antagonists are being used to treat cytokine release syndrome (CRS). Accordingly, some studies and clinical trials are investigating the effects of IL-1 beta antagonists for controlling Coronavirus disease 2019 (COVID-19) associated CRS. Here, we will review any interaction and association between IL-1 beta and SARS-CoV-2 infection.
引用
收藏
页码：16745 / 16757
页数：13
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