Stereoselective total synthesis of (-)-pyrenophorol (vol 72, pg 971, 2017)

被引：0

作者：

Ashok, Dongamanti ^{[1
]}

Pervaram, Sridhar ^{[2
]}

Chittireddy, Venkata Ramana Reddy ^{[2
]}

Reddymasu, Sreenivasulu ^{[3
]}

Vuppula, Naresh Kumar ^{[4
]}

机构：

[1] Osmania Univ, Dept Chem, Hyderabad 500007, Telangana, India

[2] Jawaharlal Nehru Technol Univ, Dept Chem, Hyderabad 500082, Telangana, India

[3] Jawaharlal Nehru Technol Univ Kakinada, Univ Coll Engn Autonomous, Dept Chem, Kakinada 533003, Andhra Pradesh, India

[4] Sri Chaitanya PG Coll, Dept Chem, Godavarikhani 505209, Telangana, India

来源：

CHEMICAL PAPERS | 2018年 / 72卷 / 04期

关键词：

(S)-ethyl lactate; (−)-Pyrenophorol; Intermolecular Mitsunobu cyclization; Wittig olefination;

D O I：

10.1007/s11696-017-0351-0

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple and efficient stereoselective synthesis of macrodilactone of (-)-pyrenophorol (1) has been accomplished in 12 steps in 8.3% overall yield, from inexpensive and commercially available (S)-ethyl lactate. This convergent synthesis utilizes an oxidation-reduction protocol and cyclodimerisation under the Mitsunobu reaction conditions as key steps. [GRAPHICS] .

引用

页码：979 / 979

页数：1

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