Association of Serum Vitamin-D and Omentin-1 Levels in Post-Menopausal Female with Coronary Artery Disease

Objective: The objective of the present study was to investigate the association between serum vita-min-D (calcidiol, D2) and omentin-1 levels in pre-and post-menopausal female patients with coronary artery disease (CAD). Methods: This cross-sectional, case-based study was conducted in cardiac ward of Civil Hospital Karachi during July 2016 to June 2017. Total 110 diagnosed female patients of coronary artery dis-ease were included randomly in the study, out of which, 42 women were pre-menopausal, whereas, 68 post-menopausal. Diagnosis was based upon coronary angiography. Serum Vitamin-D and omentin-1 levels were determined by using enzyme linked immunosorbent essay (ELISA) in Dr. Abdul Qadeer Khan Institute of Biotechnology and Genetic Engineering (KIBGE). Serum vitamin-D concentra-tions were classed as sufficient ( 30 ng/mL); deficient (10 to< 29 ng/mL); and insufficient ( <10 ng/ mL). Data was analyzed by SSPS version 16. Results: From our study we observed significant low levels of serum vitamin-D and omentin-1 in pre-and post-menopausal females of coronary artery disease, however, severe deficiency of Vitamin-D (<10 ng/L) was more associated with post-menopausal females. Vitamin-D deficiency (<30ng/L) was found in 82.72% (n=96) of CAD females, moreover; 46.36% (n=51) patients were found with severe vi-tamin-D deficiency placed in group I, 40.90% (n=45) patients were found with moderate deficiency (17.09 +/- 4 ng/mL) in group II, whereas only 12.72% (n=14) had optimal serum vitamin-D levels placed in group III. Serum vitamin-D (calcidiol, D2) level was associated positively with omentin-1 in CAD patients after adjustment for potential confounding variables; basal metabolic rate, waist circum-ference, blood pressure and lipid profile in multivariable linear regression analysis. Conclusion: Within the limits of the study, we concluded that low levels of vitamin-D and omentin-1 are associated with both pre and post-menopausal females with prevalent coronary artery disease (CAD). Further investigations are required in different ethnic groups and populations to confirm the findings.