Incidence of Diabetic Ketoacidosis of New-Onset Type 1 Diabetes in Children and Adolescents in Different Countries Correlates with Human Development Index (HDI): An Updated Systematic Review, Meta-Analysis, and Meta-Regression (vol 50, pg 209, 2018)

被引:58
|
作者
Grosse, Johann
Hornstein, Henriette
Manuwald, Ulf
Kugler, Joachim
Glauche, Ingmar
Rothe, Ulrike
机构
[1] Technische Universität Dresden, Faculty of Medicine, Carl Gustav Carus, Health Sciences/Public Health, Fetscherstrae 74, Dresden
[2] Technische Universität Dresden, Faculty of Medicine, Carl Gustav Carus, Institute for Medical Informatics and Biometry (IMB), Dresden
关键词
Drug delivery; L-leucine; maltodextrin; lipid-core nanocapsules; spray drying;
D O I
10.1055/s-0044-102090
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This study proposes a new approach to produce easily redispersible spray-dried lipid-core nanocapsules (LNC) intended for oral administration, evaluating the influence of the particle number density of the fed sample. The proposed approach to develop redispersible spray-dried LNC formulations intended for oral route is innovative, evidencing the needing of an optimization of the initial particle number density in the liquid suspension of nanocapsules. A mixture of maltodextrin and L-leucine (90:10 w/w) was used as drying adjuvant. Dynamic light scattering, turbidimetry, determination of surface area and pore size distribution, electron microscopy and confocal Raman microscopy (CRM) were used to characterize the proposed system and to better understand the differences in the redispersion behavior. An easily aqueous redispersion of the spray-dried powder composed of maltodextrin and L-leucine (90:10 w/w) was obtained, depending on the particle number density. Their surface area decreased in the presence of LNC. CRM enabled the visualization of the spatial distribution of the different compounds in the powders affording to better understand the influence of the particle number density of the fed sample on their redispersion behavior. This study shows the need for optimizing initial particle number density in the liquid formulation to develop redispersible spray-dried LNC powders.
引用
收藏
页码:e2 / e2
页数:1
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