One-Pot, Tandem Reductive Amination/Alkylation-Cycloamidation for Lactam Synthesis from Keto or Amino Acids

被引：2

作者：

Ramachandran, P. Veeraraghavan ^{[1
]}

Choudhary, Shivani ^{[1
]}

机构：

[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 22期

关键词：

LEVULINIC ACID; DIRECT AMIDATION; AMMONIA-BORANE; CATALYST; AMINATION/CYCLIZATION; PYRROLIDINES; AMINATION; HYDROAMINATION; ALKENES;

D O I：

10.1021/acs.joc.3c01126

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Monotrifluoroacetoxyborane-amines, prepared by treating borane-amines with trifluoroacetic acid, have been shown to be efficient reagents for a one-pot, tandem reductive amination/alkylation-cycloamidation of keto or amino acids to achieve the synthesis of 5-aryl or 5-methyl pyrrolidin-2-ones and 6-aryl or 6-methyl piperidin-2-ones.

引用

页码：15956 / 15963

页数：8

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