Partial agonists of dopamine receptors: mechanisms and clinical effects of aripiprazole, brexpiprazole and cariprazine

被引：6
|
作者：
Cookson, John [1 ,2 ]
Pimm, Jonathan [3 ]
机构：
[1] Royal London Hosp, Gen Adult Psychiat, London, England
[2] East London NHS Fdn Trust, Mile End Hosp, Tower Hamlets Ctr Mental Hlth, London, England
[3] East London NHS Fdn Trust, London, England
来源：
BJPSYCH ADVANCES | 2023年 / 29卷 / 02期
关键词：
Partial dopamine agonists; aripiprazole; brexpiprazole; cariprazine; antipsychotics; DOUBLE-BLIND; MAINTENANCE TREATMENT; COMPARATIVE EFFICACY; NETWORK METAANALYSIS; SCHIZOPHRENIA; PLACEBO; SAFETY; ANTIPSYCHOTICS; DISORDER; OCCUPANCY;
D O I：
10.1192/bja.2021.49
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Aripiprazole, brexpiprazole and cariprazine are partial dopamine (and serotonin) agonists developed as novel antipsychotics. This article discusses their pharmacology, evidence on their licensed and off-licence uses (including psychosis, mania, bipolar depression, Tourette syndrome and autism spectrum disorder) and side-effects. In schizophrenia, they have a low risk of Parkinsonism or hyperprolactinaemia, cause modest increases in body weight and are of moderate efficacy.
引用
收藏
页码：145 / 150
页数：6
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