Lymphangioleiomyomatosis (LAM) Cell Atlas

被引：3

作者：

Du, Yina ^{[1
,2
]}

Guo, Minzhe ^{[1
,2
]}

Wu, Yixin ^{[1
,2
]}

Wagner, Andrew ^{[1
,2
]}

Perl, Anne Karina ^{[1
,2
]}

Wikenheiser-Brokamp, Kathryn ^{[1
,2
]}

Yu, Jane ^{[3
]}

Gupta, Nishant ^{[4
]}

Kopras, Elizabeth ^{[3
]}

Krymskaya, Vera ^{[5
]}

Obraztsova, Kseniya ^{[6
]}

Tang, Yan ^{[7
]}

Kwiatkowski, David ^{[7
]}

Henske, Elizabeth P. ^{[8
]}

McCormack, Francis ^{[3
]}

Xu, Yan ^{[1
,2
]}

机构：

[1] Cincinnati Childrens Hosp Med Ctr, Perinatal Inst, Cincinnati, OH 45229 USA

[2] Cincinnati Childrens Hosp Med Ctr, Sect Neonatol Perinatal & Pulm Biol, Cincinnati, OH 45229 USA

[3] Univ Cincinnati, Coll Med, Div Pulm Crit Care & Sleep Med, Cincinnati, OH USA

[4] Univ Cincinnati, Coll Med, Cincinnati, OH USA

[5] Univ Penn, Perelman Sch Med, Med, Philadelphia, PA 19104 USA

[6] Univ Penn, Dept Med, Perelman Sch Med, Div Pulm Allergy & Crit Care Med,Lung Biol Inst, Philadelphia, PA 19104 USA

[7] Harvard Med Sch, Div Pulm & Crit Care Med, Boston, MA 02115 USA

[8] Brigham & Womens Hosp, Div Pulm & Crit Care Med, 75 Francis St, Boston, MA 02115 USA

来源：

THORAX | 2023年 / 78卷 / 01期

关键词：

rare lung diseases; idiopathic pulmonary fibrosis; lung cancer; cystic fibrosis; pulmonary lymphoma; TUBEROUS SCLEROSIS; MUTATIONS; TSC2; WOMEN;

D O I：

10.1136/thoraxjnl-2022-218772

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Lymphangioleiomyomatosis (LAM) is a rare lung disease of women, causing cystic remodelling of the lung and progressive respiratory failure. The cellular composition, microenvironment and cellular interactions within the LAM lesion remain unclear. To facilitate data sharing and collaborative LAM research, we performed an integrative analysis of single-cell data compiled from lung, uterus and kidney of patients with LAM from three research centres and developed an LAM Cell Atlas (LCA) Web-Portal. The LCA offers a variety of interactive options for investigators to search, visualise and reanalyse comprehensive single-cell multiomics data sets to reveal dysregulated genetic programmes at transcriptomic, epigenomic and cell-cell connectome levels.

引用

页码：85 / 87

页数：3

共 50 条

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