The role of sex hormones and receptors in HBV infection and development of HBV-related HCC

被引：2
|
作者：
Nuermaimaiti, Abudulimutailipu [1 ,2 ,3 ]
Chang, Le [1 ,2 ]
Yan, Ying [1 ,2 ]
Sun, Huizhen [1 ,2 ,3 ]
Xiao, Yingzi [1 ,2 ,3 ]
Song, Shi [1 ,2 ,3 ]
Feng, Kaihao [1 ,2 ,3 ]
Lu, Zhuoqun [1 ,2 ]
Ji, Huimin [1 ,2 ]
Wang, Lunan [1 ,2 ,3 ]
机构：
[1] Chinese Acad Med Sci, Beijing Hosp, Inst Geriatr Med, Natl Ctr Clin Labs,Natl Ctr Gerontol, Beijing, Peoples R China
[2] Beijing Hosp, Beijing Engn Res Ctr Lab Med, Beijing, Peoples R China
[3] Chinese Acad Med Sci & Peking Union Med Coll, Natl Ctr Clin Labs, Beijing, Peoples R China
来源：
JOURNAL OF MEDICAL VIROLOGY | 2023年 / 95卷 / 12期
关键词：
androgen receptor; estrogen receptor alpha; hepatocellular carcinoma; hormone therapy; sex hormones; HEPATITIS-B-VIRUS; UNRESECTABLE HEPATOCELLULAR-CARCINOMA; T-CELL RESPONSE; ANDROGEN-RECEPTOR; ESTROGEN-RECEPTORS; GENDER-DIFFERENCES; ALPHA EXPRESSION; CONTROLLED-TRIAL; INFLAMMATORY RESPONSES; FIBROSIS PROGRESSION;
D O I：
10.1002/jmv.29298
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Gender disparity in hepatitis B virus (HBV)-related diseases has been extensively documented. Epidemiological studies consistently reported that males have a higher prevalence of HBV infection and incidence of hepatocellular carcinoma (HCC). Further investigations have revealed that sex hormone-related signal transductions play a significant role in gender disparity. Sex hormone axes showed significantly different responses to virus entry and replication. The sex hormones axes change the HBV-specific immune responses and antitumor immunity. Additionally, Sex hormone axes showed different effects on the development of HBV-related disease. But the role of sex hormones remains controversial, and researchers have not reached a consensus on the role of sex hormones and the use of hormone therapies in HCC treatment. In this review, we aim to summarize the experimental findings on sex hormones and provide a comprehensive understanding of their roles in the development of HCC and their implications for hormone-related HCC treatment.
引用
收藏
页数：15
相关论文
共 50 条
  • [1] MicroRNAs Associated With HBV Infection And HBV-related HCC
    Xie, Kun-Lin
    Zhang, Yan-Ge
    Liu, Jun
    Zeng, Yong
    Wu, Hong
    [J]. THERANOSTICS, 2014, 4 (12): : 1176 - 1192
  • [2] Prevention of HBV-related HCC
    Liaw, Yun-Fan
    [J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2007, 22 : A6 - A6
  • [3] Risk stratification for HBV-related HCC
    Kao, Jia-Horng
    [J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2012, 27 : 1 - 1
  • [4] Therapeutic potential of genetically modified HBV-specific T cells for chronic HBV infection and HBV-related HCC
    Natalie J. Wood
    [J]. Nature Reviews Gastroenterology & Hepatology, 2011, 8 (2) : 61 - 61
  • [5] Association of HBV/inflammation and sternness expression in HBV-related HCC recurrence
    Chang, Te-Sheng
    Lee, Kam-Fai
    Lin, Hsin-Yi
    Tung, Shui-Yi
    Kuo, Liang-Mou
    Jen, Xin-Wei
    Huang, Yen-Hua
    [J]. CANCER RESEARCH, 2011, 71
  • [6] Tertiary prevention of HBV-related HCC in Asia
    Wong G.L.-H.
    Chong C.-N.
    Wong V.W.-S.
    [J]. Current Hepatitis Reports, 2013, 12 (3) : 157 - 164
  • [7] HBV-related HCC, clinical issues and therapy
    Iavarone, Massimo
    Colombo, Massimo
    [J]. DIGESTIVE AND LIVER DISEASE, 2011, 43 : S32 - S39
  • [8] Peroxisome Proliferator-Activated Receptors in HBV-Related Infection
    Dubuquoy, Laurent
    Louvet, Alexandre
    Hollebecque, Antoine
    Mathurin, Philippe
    Dharancy, Sebastien
    [J]. PPAR RESEARCH, 2009, 2009
  • [9] Unveiling NUSAP1 as a common gene signature linking chronic HBV infection and HBV-related HCC
    Meng, Jiao
    Yang, Zhenkun
    Jiang, Xinyi
    Zou, Jian
    [J]. DISCOVER ONCOLOGY, 2024, 15 (01)
  • [10] Benefit of Antiviral Therapy for HBV-Related HCC with Undetectable HBV DNA Is Still Dubious
    Giri, Suprabhat
    Darak, Harish
    Kasturi, Sunil
    [J]. DIGESTIVE DISEASES AND SCIENCES, 2022, 67 (10) : 4962 - 4964
12345