Off-label Prescription in Paediatric Dermatology: A Retrospective Observational Study in a Tertiary Hospital

被引:0
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作者
Couselo-Rodriguez, Carmen [1 ,2 ,4 ]
Batalla, Ana [1 ,2 ]
Martinez-Fernandez, Sandra [1 ,2 ]
Davila-Pousa, Carmela [3 ]
Soto-Garcia, Diego [1 ,2 ]
Vilanova-trillo, Lucia [1 ,2 ]
Florez, Angeles [1 ,2 ]
机构
[1] Univ Hosp Pontevedra, Dept Dermatol, Pontevedra, Spain
[2] Galicia Sur Hlth Res Inst IIS Galicia Sur, DIPO Res Grp, Sergas Uvigo, Vigo, Spain
[3] Complejo Hosp Univ Pontevedra, Dept Pharm, Pontevedra, Spain
[4] Ctr Especialidades Mollabao, Ctr Especialidades Mollabao, Rua Simon Bolivar S-N, ES-36003 Pontevedra, Spain
关键词
child; dermatology; off-label use; prevalence; pa-ediatrics; CHILDREN;
D O I
10.2340/actadv.v102.11937
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Off-label prescription in paediatric patients is common, where some studies indicate that dermatological conditions are more prone to off-label treatment. This is the first study to analyse the prevalence of off-label prescription in paediatric dermatology consultation. This retrospective observational study was performed using the medical records of paediatric patients who were evaluated in a paediatric dermatological consultation in Pontevedra University Hospital, Pontevedra, Spain. Of the 468 patients reviewed, 186 prescriptions were issued and 51.10% were off-label prescription drugs. The dermatological conditions for which off-label prescription was most common were atopic dermatitis (29.0%), followed by warts (12.9%) and infantile haemangiomas (11.8%). With respect to drugs, topical tacrolimus (23.7%) was the most frequently prescribed off-label drug. The main reason for prescribing an off-label drug was for a disease not included on the label (62.4%), followed by issuing it at a lower age than authorized (55.9%). There was a significant association between a higher percentage of off-label prescription and younger age (p < 0.001), and the treatment of vitiligo, infantile haemangiomas and warts (p < 0.001). Likewise, the off-label prescription was significantly more common in the case of topical terbinafine, timolol, desloratadine and topical salicylic acid (p < 0.001). To conclude, off-label prescription is predominant in paediatric dermatology, as observed in 51.1% of our patients.
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页数:5
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