Advances in saRNA Vaccine Research against Emerging/Re-Emerging Viruses

被引：7
|
作者：
Liu, Yalan [1 ,2 ]
Li, Yuncheng [1 ,3 ]
Hu, Qinxue [1 ,4 ]
机构：
[1] Chinese Acad Sci, Wuhan Inst Virol, Ctr Biosafety Mega Sci, State Key Lab Virol, Wuhan 430071, Peoples R China
[2] Hubei Jiangxia Lab, Wuhan 430200, Peoples R China
[3] Univ Chinese Acad Sci, Savaid Med Sch, Beijing 101408, Peoples R China
[4] St Georges Univ London, Inst Infect & Immun, London SW17 0RE, England
来源：
VACCINES | 2023年 / 11卷 / 07期
基金：
中国国家自然科学基金;
关键词：
vaccine; self-amplifying RNA (saRNA); emerging; re-emerging virus; MESSENGER-RNA VACCINES; RESPIRATORY SYNCYTIAL VIRUS; HIV TYPE-1 ENVELOPE; INFLUENZA-A VIRUS; IMMUNE-RESPONSES; CATIONIC LIPIDS; PROTECTIVE EFFICACY; PROTEIN EXPRESSION; NONVIRAL DELIVERY; RISK-FACTORS;
D O I：
10.3390/vaccines11071142
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Although conventional vaccine approaches have proven to be successful in preventing infectious diseases in past decades, for vaccine development against emerging/re-emerging viruses, one of the main challenges is rapid response in terms of design and manufacture. mRNA vaccines can be designed and produced within days, representing a powerful approach for developing vaccines. Furthermore, mRNA vaccines can be scaled up and may not have the risk of integration. mRNA vaccines are roughly divided into non-replicating mRNA vaccines and self-amplifying RNA (saRNA) vaccines. In this review, we provide an overview of saRNA vaccines, and discuss future directions and challenges in advancing this promising vaccine platform to combat emerging/re-emerging viruses.
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页数：16
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