Design, Synthesis, and Biological Evaluation of Some New N-(Substituted Pyridine-3-yl)-1,3,4-Oxadiazol-2-Amines

被引：0
|
作者：
Patil, Priyanka A. [1 ,2 ]
Khulbe, Preeti [1 ]
Magdum, Chandrakant S. [3 ]
机构：
[1] Suresh GyanVihar Univ, Sch Pharm, Dept Pharmaceut Chem, Jaipur, Rajasthan, India
[2] Dr Shivajirao Kadam Coll Pharm, Dept Pharmaceut Chem, Sangli, Maharashtra, India
[3] Rajarambapu Coll Pharm, Dept Pharmaceut Chem, Sangli, Maharashtra, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2023年 / 33卷 / 01期
关键词：
MCF-7; Cytotoxicity; 1,3,4 Oxadiazole; HepG2; ANTICANCER; 1,3,4-OXADIAZOLE; DERIVATIVES; ANALOGS;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of some new oxadiazole derivatives was synthesized from substituted aryl isothiocyanates. All newly synthesized compounds were evaluated for in vitro cytotoxic activity on two standardized human cell lines, MCF 7 (breast cancer), and HepG2 (human liver cancer). Cytotoxicity was measured by MTT assay, the preliminary bioassay showed that most of the compounds had better antiproliferatory activity. Among the compounds evaluated, compound N-(4-methylphenyl)-5-(pyridin-3-yl)-1,3,4-oxadiazol-2-amine(3g) exhibited the significant cytotoxic property against MCF-7 (IC 50 = 29.25 )mu M) and compound N-(3-bromophenyl)-5-(pyridin-3-yl)-1,3,4-oxadiazol-2-amine (3j) exhibited the highest cytotoxic activity against HepG-2 tumor cell lines (IC 50 = 25.73 )mu M).
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页码：71 / 78
页数：8
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