Oleanolic acid and ursolic acid: therapeutic potential in neurodegenerative diseases, neuropsychiatric diseases and other brain disorders

被引：13

作者：

Chen, Chen ^{[1
]}

Ai, Qidi ^{[2
,3
]}

Shi, Axi ^{[1
]}

Wang, Nan ^{[4
]}

Wang, Lina ^{[5
]}

Wei, Yuhui ^{[1
]}

机构：

[1] Lanzhou Univ, Dept Pharm, Hosp 1, Lanzhou 730000, Peoples R China

[2] Hunan Univ Tradit Chinese Med, Hunan Engn Technol Ctr Standardizat & Funct Chine, Changsha, Peoples R China

[3] Hunan Univ Tradit Chinese Med, Coll Pharm, Changsha, Peoples R China

[4] Lanzhou Univ, Dept Gen Med, Hosp 1, Lanzhou, Peoples R China

[5] Lanzhou Univ, Dept Pediat Surg, Hosp 1, Lanzhou, Peoples R China

来源：

NUTRITIONAL NEUROSCIENCE | 2023年 / 26卷 / 05期

关键词：

Oleanolic acid; Ursolic acid; neurodegenerative disease; neuropsychiatric disease; brain disorder; neurological disease; natural product; phytochemical; INDUCED COGNITIVE DEFICITS; STEAROYL GLUCOSIDE; ORAL BIOAVAILABILITY; MULTIPLE-SCLEROSIS; OXIDATIVE STRESS; OFFICINALIS L; CORNI-FRUCTUS; IN-SILICO; MICE; INJURY;

D O I：

10.1080/1028415X.2022.2051957

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brain disorders such as neurodegenerative diseases and neuropsychiatric diseases have become serious threatens to human health and quality of life. Oleanolic acid (OA) and ursolic acid (UA) are pentacyclic triterpenoid isomers widely distributed in various plant foods and Chinese herbal medicines. Accumulating evidence indicates that OA and UA exhibit neuroprotective effects on multiple brain disorders. Therefore, this paper reviews researches of OA and UA on neurodegenerative diseases, neuropsychiatric diseases and other brain disorders including ischemic stroke, epilepsy, etc, as well as the potential underlying molecular mechanisms. [GRAPHICS]

引用

页码：414 / 428

页数：15

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