cancer chaotic mode;
fractal-fractional calculus;
existence and uniqueness;
Grunwald-Letnikov nonstandard finite difference method;
stability;
CHAOS;
ATTRACTORS;
STABILITY;
D O I:
10.3934/mbe.2023803
中图分类号:
Q [生物科学];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
The mathematical oncology has received a lot of interest in recent years since it helps illuminate pathways and provides valuable quantitative predictions, which will shape more effective and focused future therapies. We discuss a new fractal-fractional-order model of the interaction among tumor cells, healthy host cells and immune cells. The subject of this work appears to show the relevance and ramifications of the fractal-fractional order cancer mathematical model. We use fractal-fractional derivatives in the Caputo senses to increase the accuracy of the cancer and give a mathematical analysis of the proposed model. First, we obtain a general requirement for the existence and uniqueness of exact solutions via Perov's fixed point theorem. The numerical approaches used in this paper are based on the Grunwald-Letnikov nonstandard finite difference method due to its usefulness to discretize the derivative of the fractal-fractional order. Then, two types of stabilities, Lyapunov's and Ulam-Hyers' stabilities, are established for the Incommensurate fractional-order and the Incommensurate fractalfractional, respectively. The numerical results of this study are compatible with the theoretical analysis. Our approaches generalize some published ones because we employ the fractal-fractional derivative in the Caputo sense, which is more suitable for considering biological phenomena due to the significant memory impact of these processes. Aside from that, our findings are new in that we use Perov's fixed point result to demonstrate the existence and uniqueness of the solutions. The way of expressing the Ulam-Hyers' stabilities by utilizing the matrices that converge to zero is also novel in this area.
机构:
Univ Victoria, Dept Math & Stat, Victoria, BC V8W 3R4, Canada
China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung 40402, Taiwan
Azerbaijan Univ, Dept Math & Informat, 71 Jeyhun Hajibeyli St, AZ-1007 Baku, AzerbaijanUniv Victoria, Dept Math & Stat, Victoria, BC V8W 3R4, Canada
Srivastava, H. M.
Saad, Khaled M.
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机构:
Najran Univ, Coll Sci & Arts, Dept Math, POB 1988, Najran, Saudi Arabia
Taiz Univ, Fac Appl Sci, Dept Math, POB 6803, Taizi, YemenUniv Victoria, Dept Math & Stat, Victoria, BC V8W 3R4, Canada
机构:
Univ Free State, Fac Nat & Agr Sci, Intitute Ground Water Studies, Bloemfontein, South Africa
Mehran Univ Engn & Technol, Dept Basic Sci & Related Studies, Jamshoro, PakistanUniv Free State, Fac Nat & Agr Sci, Intitute Ground Water Studies, Bloemfontein, South Africa
机构:
Department of Applied Mathematics, University of California Merced, Merced,CA, United StatesDepartment of Applied Mathematics, University of California Merced, Merced,CA, United States
Partohaghighi, Mohammad
Mortezaee, Marzieh
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h-index: 0
机构:
Faculty of Mathematical Sciences, Shahrood University of Technology, Shahrood, IranDepartment of Applied Mathematics, University of California Merced, Merced,CA, United States
Mortezaee, Marzieh
Akgül, Ali
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h-index: 0
机构:
Near East University, Mathematics Research Center Department of Mathematics, Near East Boulevard PC, Nicosia/Mersin 10,99138, Turkey
Department of Computer Science and Mathematics, Lebanese American University, Beirut, Lebanon
Siirt University, Art and Science Faculty Department of Mathematics, Siirt,56100, TurkeyDepartment of Applied Mathematics, University of California Merced, Merced,CA, United States
Akgül, Ali
Hassan, Ahmed M.
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h-index: 0
机构:
Faculty of engineering, Future University in Egypt, EgyptDepartment of Applied Mathematics, University of California Merced, Merced,CA, United States
Hassan, Ahmed M.
Sakar, Necibullah
论文数: 0引用数: 0
h-index: 0
机构:
Siirt University, Art and Science Faculty Department of Mathematics, Siirt,56100, TurkeyDepartment of Applied Mathematics, University of California Merced, Merced,CA, United States