Circulating Tumor DNA in Head and Neck Squamous Cell Carcinoma

被引：0
|
作者：
Brandt, Anna [1 ]
Thiele, Benjamin [2 ]
Schultheiss, Christoph [3 ]
Daetwyler, Eveline [4 ]
Binder, Mascha [3 ,4 ]
机构：
[1] Univ Hosp Erlangen, Dept Internal Med Hematol & Oncol 5, D-91054 Erlangen, Germany
[2] Univ Med Ctr Hamburg Eppendorf, Dept Oncol Hematol & Bone Marrow Transplantat Sect, D-20251 Hamburg, Germany
[3] Martin Luther Univ Halle Wittenberg, Internal Med Oncol Hematol 4, Ernst Grube Str 40, D-06120 Halle, Germany
[4] Univ Hosp Basel, Div Med Oncol, CH-4031 Basel, Switzerland
来源：
CANCERS | 2023年 / 15卷 / 07期
关键词：
head and neck squamous cell carcinoma (HNSCC); cell-free DNA (cfDNA); liquid biopsy; monitoring; resistance; prognostication; EVOLUTIONARY ACTION SCORE; AND/OR METASTATIC HEAD; POSITIVE SOLID TUMORS; LOCALLY ADVANCED HEAD; LIQUID BIOPSY; TP53; MUTATIONS; PLATINUM-RESISTANT; MOLECULAR-BIOLOGY; SURVIVAL OUTCOMES; RECURRENT HEAD;
D O I：
10.3390/cancers15072051
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tumors shed cell-free DNA (cfDNA) into the plasma. "Liquid biopsies" are a diagnostic test to analyze cfDNA in order to detect minimal residual cancer, profile the genomic tumor landscape, and monitor cancers non-invasively over time. This technique may be useful in patients with head and neck squamous cell carcinoma (HNSCC) due to genetic tumor heterogeneity and limitations in imaging sensitivity. However, there are technical challenges that need to be overcome for the widespread use of liquid biopsy in the clinical management of these patients. In this review, we discuss our current understanding of HNSCC genetics and the role of cfDNA genomic analyses as an emerging precision diagnostic tool.
引用
收藏
页数：19
相关论文
共 50 条
  • [1] Individualized circulating tumor DNA monitoring in head and neck squamous cell carcinoma
    Kogo, Ryunosuke
    Manako, Tomomi
    Iwaya, Takeshi
    Nishizuka, Satoshi
    Hiraki, Hayato
    Sasaki, Yasushi
    Idogawa, Masashi
    Tokino, Takashi
    Koide, Ayaka
    Komune, Noritaka
    Yasumatsu, Ryuji
    Nakagawa, Takashi
    [J]. CANCER MEDICINE, 2022, 11 (21): : 3960 - 3968
  • [2] Utility of plasma circulating tumor DNA and tumor DNA profiles in head and neck squamous cell carcinoma
    Chikuie, Nobuyuki
    Urabe, Yuji
    Ueda, Tsutomu
    Hamamoto, Takao
    Taruya, Takayuki
    Kono, Takashi
    Yumii, Kohei
    Takeno, Sachio
    [J]. SCIENTIFIC REPORTS, 2022, 12 (01)
  • [3] Utility of plasma circulating tumor DNA and tumor DNA profiles in head and neck squamous cell carcinoma
    Nobuyuki Chikuie
    Yuji Urabe
    Tsutomu Ueda
    Takao Hamamoto
    Takayuki Taruya
    Takashi Kono
    Kohei Yumii
    Sachio Takeno
    [J]. Scientific Reports, 12
  • [4] Circulating tumor DNA as a biomarker and liquid biopsy in head and neck squamous cell carcinoma
    Payne, Karl
    Spruce, Rachel
    Beggs, Andrew
    Sharma, Neil
    Kong, Anthony
    Martin, Timothy
    Parmar, Satyesh
    Praveen, Prav
    Nankivell, Paul
    Mehanna, Hisham
    [J]. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2018, 40 (07): : 1598 - 1604
  • [5] Liquid biopsy in head and neck squamous cell carcinoma: circulating tumor cells, circulating tumor DNA, and exosomes
    Yang, Wen-Ying
    Feng, Lin-Fei
    Meng, Xiang
    Chen, Ran
    Xu, Wen-Hua
    Hou, Jun
    Xu, Tao
    Zhang, Lei
    [J]. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2020, 20 (12) : 1213 - 1227
  • [6] Tumor-Naive Multimodal Profiling of Circulating Tumor DNA in Head and Neck Squamous Cell Carcinoma
    Burgener, Justin M.
    Zou, Jinfeng
    Zhao, Zhen
    Zheng, Yangqiao
    Shen, Shu Yi
    Huang, Shao Hui
    Keshavarzi, Sareh
    Xu, Wei
    Liu, Fei-Fei
    Liu, Geoffrey
    Waldron, John N.
    Weinreb, Ilan
    Spreafico, Anna
    Siu, Lillian L.
    de Almeida, John R.
    Goldstein, David P.
    Hoffman, Michael M.
    De Carvalho, Daniel D.
    Bratman, Scott V.
    [J]. CLINICAL CANCER RESEARCH, 2021, 27 (15) : 4230 - 4244
  • [7] Feasibility of Circulating Cell-Free Tumor DNA as a Biomarker in Head and Neck Squamous Cell Carcinoma
    Egyud, Matthew R.
    Saunders, Stefanie S.
    Devaiah, Anand K.
    Jalisi, Scharukh
    Godfrey, Tony E.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2017, 225 (04) : S191 - S192
  • [8] Circulating tumour DNA as a biomarker in head and neck squamous cell carcinoma
    Jia, N.
    Zhang, S.
    Chen, Y.
    Shi, X.
    Chen, X.
    Zhang, T.
    Bai, C.
    [J]. ANNALS OF ONCOLOGY, 2020, 31 : S678 - S678
  • [9] Current applications and challenges of circulating tumor DNA (ctDNA) in squamous cell carcinoma of the head and neck (SCCHN)
    Galot, Rachel
    Machiels, Jean-Pascal H.
    [J]. CANCER TREATMENT REVIEWS, 2020, 85
  • [10] Circulating Tumor Cells Correlate With Prognosis in Head and Neck Squamous Cell Carcinoma
    Zhou, Shichao
    Wang, Lili
    Zhang, Wenying
    Liu, Feng
    Zhang, Yanjie
    Jiang, Bin
    Wang, JiongYi
    Yuan, Haihua
    [J]. TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 2021, 20
12345