Neoadjuvant therapy in non-small cell lung cancer

被引：4
|
作者：
Grant, Christopher [1 ]
Hagopian, Garo [1 ]
Nagasaka, Misako [1 ,2 ,3 ,4 ]
机构：
[1] Univ Calif Irvine, Sch Med, Dept Med, Orange, CA USA
[2] Univ Calif Irvine, Sch Med, Dept Med, Div Hematol & Oncol, Orange, CA USA
[3] St Marianna Univ, Sch Med, Dept Internal Med, Div Neurol, Kawasaki 2168511, Japan
[4] Univ Calif Irvine, UC Irvine Hlth, Med Ctr, Dept Med,Div Hematol & Oncol, 200 S Manchester Ave, Room 423, Orange, CA 92868 USA
来源：
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2023年 / 190卷
关键词：
Perioperative chemotherapy; Perioperative immunotherapy; Neoadjuvant targeted therapy; CheckMate; 816; AEGEAN; PHASE-III; INDUCTION CHEMOTHERAPY; PLUS CHEMOTHERAPY; OPEN-LABEL; SURGERY; TRIAL; PEMBROLIZUMAB; OSIMERTINIB;
D O I：
10.1016/j.critrevonc.2023.104080
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Non-small cell lung cancer (NSCLC) stages I-III were previously predominantly treated with surgery and chemotherapy. With the advent of Checkmate-816, neoadjuvant nivolumab and chemotherapy was FDA approved for the treatment of resectable NSCLC. There are several ongoing trials evaluating other neoadjuvant combinations of chemotherapy and immunotherapy as well as targeted therapies towards driver mutations. Here, we review previous clinical trials and discuss current ongoing trials' potential benefits and challenges.
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页数：8
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