Arenga westerhoutii Griff.: bioactive constituents, nutraceuticals, antioxidant and anti-diabetic potential of stem extract and an insight into molecular docking analysis

被引：2
|
作者：
Borah, Nirangkush [1 ,2 ]
Chetia, Pankaj [3 ]
Tamuly, Chandan [1 ,2 ]
机构：
[1] CSIR North East Inst Sci & Technol, Itanagar, Arunachal Prade, India
[2] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India
[3] Dibrugarh Univ, Dept Life Sci, Dibrugarh, Assam, India
来源：
NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 13期
关键词：
nutraceuticals; chlorogenic acid; ferulic acid; epicatechin; molecular docking;
D O I：
10.1080/14786419.2022.2037085
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Herein, we reported a systematic scientific study of Arenga westerhoutii Griff. by evaluating its bioactive components, nutraceuticals, antioxidant and anti-diabetic properties. Three major bioactive compounds were identified using HPLC and HRMS. Quantification of the components through HPLC yielded the presence of 75.67 +/- 0.05, 38.19 +/- 0.10 and 13.11 +/- 0.02 mu g/mL of chlorogenic acid, ferulic acid and epicatechin respectively in 1 mg/ml of the extract. 50% MeOH hydro-alcoholic extract was found to show lowest IC50 value in both in-vitro antioxidant (IC50 = 2.925 +/- 0.12 mu g/mL, DPPH assay) and anti-diabetic assays (IC50 = 18.03 +/- 0.18 mu g/mL, alpha-glucosidase assay). Further analysis by molecular docking study suggested the interaction of components towards alpha-glucosidase enzyme.
引用
收藏
页码：2293 / 2297
页数：5
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    Sertsemariam, Woldie
    Thiruvengadam, Muthu
    Pandiaraj, Saravanan
    Rahaman, Mostafizur
    Rajeswari, V. Devi
    [J]. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2024,
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    Danish, Muhammad
    Rashid, Umer
    Mukhtar, Hamid
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    Ul-Haq, Zaheer
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    [J]. OPEN CHEMISTRY, 2024, 22 (01):
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