Arenga westerhoutii Griff.: bioactive constituents, nutraceuticals, antioxidant and anti-diabetic potential of stem extract and an insight into molecular docking analysis

Herein, we reported a systematic scientific study of Arenga westerhoutii Griff. by evaluating its bioactive components, nutraceuticals, antioxidant and anti-diabetic properties. Three major bioactive compounds were identified using HPLC and HRMS. Quantification of the components through HPLC yielded the presence of 75.67 +/- 0.05, 38.19 +/- 0.10 and 13.11 +/- 0.02 mu g/mL of chlorogenic acid, ferulic acid and epicatechin respectively in 1 mg/ml of the extract. 50% MeOH hydro-alcoholic extract was found to show lowest IC50 value in both in-vitro antioxidant (IC50 = 2.925 +/- 0.12 mu g/mL, DPPH assay) and anti-diabetic assays (IC50 = 18.03 +/- 0.18 mu g/mL, alpha-glucosidase assay). Further analysis by molecular docking study suggested the interaction of components towards alpha-glucosidase enzyme.