Conditioned nausea induced by cisplatin and emetine identified by a taste reactivity test in rats

被引：0
|
作者：
Su, Shaoyi [1 ,2 ]
Wei, Zimo [1 ,2 ]
Huang, Helai [1 ,2 ]
Yoshizawa, Tomohiko [1 ,2 ]
Inui, Tadashi [1 ,2 ]
Funahashi, Makoto [1 ,2 ,3 ]
机构：
[1] Hokkaido Univ, Fac Dent Med, Dept Oral Funct Sci, Oral Physiol,Div Oral Med Sci, Sapporo, Japan
[2] Hokkaido Univ, Grad Sch Dent Med, Sapporo, Japan
[3] Hokkaido Univ, Dept Oral Physiol, Grad Sch Dent Med, Kita 13,Nishi 7,Kita Ku, Sapporo 0608586, Japan
来源：
PHYSIOLOGY & BEHAVIOR | 2023年 / 269卷
关键词：
Conditioned nausea; Gaping; Conditioned taste aversion; Cisplatin; Emetine; Taste reactivity test; Rats; 5-HT3 RECEPTOR ANTAGONIST; VAGAL AFFERENT-FIBERS; AREA POSTREMA LESIONS; BRAIN FOS EXPRESSION; ANTICIPATORY NAUSEA; INDUCED EMESIS; INDUCED PICA; ADJUVANT CHEMOTHERAPY; AVERSION; 5-HYDROXYTRYPTAMINE;
D O I：
10.1016/j.physbeh.2023.114278
中图分类号：
B84 [心理学];
学科分类号：
04 ; 0402 ;
摘要：
No prior studies have shown that gaping reactions are produced with the avoidance of conditioned taste caused by cisplatin and emetine. Therefore, we tried to demonstrate it using a taste reactivity test in rats and found the gaping reactions induced when saccharin is readministered after gustatory conditioning that paired saccharin with cisplatin or emetine. Since conditioned gaping reactions indicate the aversion to saccharin taste and conditioned nausea, the present study suggest that the taste aversion is induced by cisplatin and emetine. It was also found that with intraperitoneal injections of emetine alone, gaping almost never occurs.
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页数：6
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