Targeted Ultrasound Nanobubbles Therapy for Prostate Cancer via Immuno-Sonodynamic Effect

被引:1
|
作者
Huang, Xin [1 ]
Chen, Yueying [1 ]
Zhong, Fanglu [1 ]
Gui, Bin [1 ]
Hu, Yugang [1 ]
Guo, Yuxin [1 ]
Deng, Qing [1 ,2 ]
Zhou, Qing [1 ,2 ]
机构
[1] Wuhan Univ, Renmin Hosp, Dept Ultrasound, Wuhan 430060, Peoples R China
[2] Wuhan Univ, Renmin Hosp, Dept Ultrasound, 238 Jiefang Rd, Wuhan 430060, Peoples R China
来源
基金
中国国家自然科学基金;
关键词
Ce6; nanobubbles; ultrasound; sonodynamic therapy; immunotherapy; RECENT PROGRESS; SONOSENSITIZERS; IMMUNOTHERAPY; DOCETAXEL; AGENTS;
D O I
10.2147/IJN.S451179
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Background: Prostate cancer (PCa) poses a significant global health threaten. Immunotherapy has emerged as a novel strategy to augment the inhibition of tumor proliferation. However, the sole use of anti-PD-L1 Ab for PCa has not yielded improvements, mirroring outcomes observed in other tumor types. Methods: This study employed the thin film hydration method to develop lipid nanobubbles (NBs) encapsulating chlorin e6 (Ce6) and anti-PD-L1 Ab (Ce6@aPD-L1 NBs). Our experimental approach included cellular assays and mouse immunization, providing a comprehensive evaluation of Ce6@aPD-L1 NBs' impact. Results: The Ce6@aPD-L1 NBs effectively induced reactive oxygen species generation, leading to tumor cells death. In mice, they demonstrated a remarkable enhancement of immune responses compared to control groups. These immune responses encompassed immunogenic cell death induced by sonodynamic therapy and PD-1/PD-L1 blockade, activating dendritic cells maturation and effectively stimulating CD8+T cells. Conclusion: Ce6@aPD-L1 NBs facilitate tumor-targeted delivery, activating anti-tumor effects through direct sonodynamic therapy action and immune system reactivation in the tumor microenvironment. Ce6@aPD-L1 NBs exhibit substantial potential for achieving anti-cancer effects in PCa.
引用
收藏
页码:2793 / 2806
页数:14
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