Anthropogenic activities are the major source of chemical pollutants including heavy metals in the coastal ecosystem which may accumulate in the aquatic organisms through the food web. Metal contamination in the marine fish pose serious threat to human health. This study deals with the human health risks of metal accumulation from Sarda orientalis consumption. The quantities of heavy metals were investigated in muscle, gills, and liver of striped bonito from the commercial landings of Karachi Fish Harbor, Pakistan (northern Arabian Sea). Risk for human health was evaluated by iron, zinc, manganese, copper, lead, cadmium, estimated daily intake, hazard index, and risk index. The hazard index value is <1, indicating that the estimated exposure is below reference dose for the relevant metals for monsoon, winter, and pre-monsoon. The mean hazard index for iron, zinc, manganese, copper, lead, and cadmium was 1.20 x 10(-2) for consumers. The mean risk index of lead for S. orientalis was 7.39 x 10(-9). As a result, the metals did not exceed the World Health Organization's and the United States Environmental Protection Agency's toxicological reference.