The Amazing History of Methotrexate - 75 Years Later from its Discovery, Still the "Golden Standard" Therapy

被引：0

作者：

Ancuta, Ion ^{[1
,2
]}

Nedelcu, Irinel A. ^{[3
]}

Stoleriu, Gabriela ^{[4
]}

Branisteanu, Daciana E. ^{[5
,6
]}

机构：

[1] Carol Davila Univ Med & Pharm, 37 Dionisie Lupu St, Bucharest 050474, Romania

[2] Dr I Cantacuzino Clin Hosp, Dept Rheumatol, Loan Movila St 5-7, Bucharest 020475, Romania

[3] Colentina Clin Hosp, Dermatol Dept 2, Soseaua Stefan Cel Mare 19-21, Bucharest, Romania

[4] Univ Galatzi, Fac Med & Pharm, Clin Dept, Galati 800008, Romania

[5] Grigore T Popa Univ Med & Pharm, Dept Dermatol, Iasi 700115, Romania

[6] Railway Clin Hosp, Dept Dermatol, Iasi 700506, Romania

来源：

ROMANIAN JOURNAL OF MILITARY MEDICINE | 2023年 / 126卷 / 01期

关键词：

methotrexate; treatment; rheumatoid arthritis; psoriasis; history; RHEUMATOID-ARTHRITIS; POLYAMINE LEVELS; TISSUE REACTIVITY; CYTOKINE RELEASE; ADENOSINE; INHIBITION; TRANSFORMYLASE; POLYGLUTAMATION; LYMPHOCYTES; SUPPRESSION;

D O I：

10.55453/rjmm.2023.126.1.1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

More than 75 years after its accidental discovery, methotrexate remains an important treatment option for many diseases. Whether it is various hematological and non-hematological neoplasms, rheumatological, dermatological, or other conditions, methotrexate remains in scope. For rheumatoid arthritis, current clinical guidelines (EULAR, ACR) recommend methotrexate as the first therapeutic option. This article aims to highlight important moments in the history of this remarkable drug, to review the literature on its mechanisms of action and the arguments for which after more than half a century, methotrexate remains the gold standard in the treatment of rheumatoid arthritis but also an important option for treatment of psoriasis vulgaris (PV) and psoriatic arthritis (PsA).

引用

页码：3 / 9

页数：7

共 3 条

[1] 150years of Friedreich Ataxia: from its discovery to therapy PREFACE
Schulz, Joerg B.
Pandolfo, Massimo
[J]. JOURNAL OF NEUROCHEMISTRY, 2013, 126 : 1 - 3
[2] The centennial of oxygen-therapy (1902-2002) -: Reassessing its history -: Part 1:: "The long way of oxygen" -: From its discovery to its implementation as a rational therapy in anaesthesia and emergency-medicine
Strätling, M
Schmucker, P
[J]. ANASTHESIOLOGIE INTENSIVMEDIZIN NOTFALLMEDIZIN SCHMERZTHERAPIE, 2002, 37 (12): : 712 - +
[3] Comparing notes with Lewis and Clark - A present-day adventurer canoes the Upper Missouri to find that time and fortune have erased signs of its later history, restoring the wilderness the Corps of Discovery penetrated nearly 200 years ago
Allen, L
[J]. AMERICAN HERITAGE, 2003, 54 (02) : 42 - 51

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