Phosphoinositide 3-kinase as a therapeutic target in angiogenic disease

被引：1

作者：

Wu, Wenyi ^{[1
,2
,3
,7
]}

Xia, Xiabo ^{[1
,2
,3
]}

Tang, Luosheng ^{[4
]}

Luo, Jing ^{[4
]}

Xiong, Siqi ^{[1
,2
,3
]}

Ma, Gaoen ^{[5
,8
]}

Lei, Hetian ^{[6
,9
]}

机构：

[1] Cent South Univ, Xiangya Hosp, Dept Ophthalmol, Changsha, Peoples R China

[2] Hunan Key Lab Ophthalmol, Changsha, Peoples R China

[3] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China

[4] Cent South Univ, Xiangya Hosp 2, Dept Ophthalmol, Changsha, Hunan, Peoples R China

[5] Hainan Med Univ, Dept Cardiothorac Surg, Affiliated Hosp 1, Haikou 570102, Hainan, Peoples R China

[6] Jinan Univ, Shenzhen Eye Hosp, Shenzhen Eye Inst, Shenzhen, Peoples R China

[7] 87 Xiangya Rd, Changsha, Peoples R China

[8] 3 Xueyuan Rd, Haikou 571199, Peoples R China

[9] 18 Zetian Rd, Shenzhen 518000, Peoples R China

来源：

EXPERIMENTAL EYE RESEARCH | 2023年 / 236卷

基金：

中国国家自然科学基金;

关键词：

PI3K; Isoform inhibitors; Akt; Inflammation; Angiogenesis; ENDOTHELIAL GROWTH-FACTOR; PROTEIN-KINASE-B; PHOSPHATIDYLINOSITOL; 3-KINASE; PI3K PATHWAY; TNF-ALPHA; PATHOLOGICAL ANGIOGENESIS; INHIBITS ANGIOGENESIS; VASCULAR MATURATION; P110-ALPHA ISOFORM; AKT PROTOONCOGENE;

D O I：

10.1016/j.exer.2023.109646

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Phosphoinositide 3-kinases (PI3Ks) generate lipids that control multitudinous intracellular cell signaling events which participate in cell survival and proliferation. In addition, PI3K signaling also contributes to metabolism, immunity, angiogenesis and cardiovascular homeostasis, and many diseases. The diverse actions of PI3K stem from the existence of their various isoforms and a variety of protein effectors. Hence, PI3K isoform-specific inhibitors have already achieved a wonderful effect on treating cancer. Herein, we summarize the molecular mechanism of PI3K inhibitors in preventing the permeability of vessels and neovascularization. Additionally, we briefly illustrate how PI3K signaling modulates blood vessel growth and discuss the different roles that PI3K isoforms play in angiogenesis.

引用

页数：10

共 50 条

[1] A TARGET FOR PHOSPHOINOSITIDE 3-KINASE - AKT/PKB
BOS, JL
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 1995, 20 (11) : 441 - 442
[2] Therapeutic potential of phosphoinositide 3-kinase inhibitors
Drees, BE
Mills, GB
Rommel, C
Prestwich, GD
[J]. EXPERT OPINION ON THERAPEUTIC PATENTS, 2004, 14 (05) : 703 - 732
[3] The Phosphoinositide 3-Kinase Signaling Pathway as a Therapeutic Target in Grade IV Brain Tumors
Hoeland, K.
Salm, F.
Arcaro, A.
[J]. CURRENT CANCER DRUG TARGETS, 2011, 11 (08) : 894 - 918
[4] Phosphoinositide 3-kinase signalling - which way to target?
Wymann, MP
Zvelebil, M
Laffargue, M
[J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 2003, 24 (07) : 366 - 376
[5] Therapeutic potential of review phosphoinositide 3-kinase inhibitors
Ward, S
Sotsios, Y
Dowden, J
Bruce, I
Finan, P
[J]. CHEMISTRY & BIOLOGY, 2003, 10 (03): : 207 - 213
[6] Phosphoinositide 3-kinase β, phosphoinositide 3-kinase δ, and phosphoinositide 3-kinase γ mediate the anti-inflammatory effects of magnesium sulfate
Lee, Ping-Ying
Yang, Chen-Hsien
Kao, Ming-Chang
Su, Nuan-Yen
Tsai, Pei-Shan
Huang, Chun-Jen
[J]. JOURNAL OF SURGICAL RESEARCH, 2015, 197 (02) : 390 - 397
[7] Phosphoinositide 3-kinase
Cantley, LC
[J]. FASEB JOURNAL, 1998, 12 (08): : A1312 - A1312
[8] PI 3-kinase inhibition: a therapeutic target for respiratory disease
Finan, PM
Thomas, MJ
[J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 2004, 32 : 378 - 382
[9] The phosphoinositide 3-kinase signalling pathway as a therapeutic target in squamous cell carcinoma of the head and neck
Rogers, SJ
Box, C
Harrington, KJ
Nutting, C
Rhys-Evans, P
Eccles, SA
[J]. EXPERT OPINION ON THERAPEUTIC TARGETS, 2005, 9 (04) : 769 - 790
[10] Phosphoinositide 3-kinase: From viral oncoprotein to drug target
Vogt, PK
Bader, AG
Kang, S
[J]. VIROLOGY, 2006, 344 (01) : 131 - 138

← 1 2 3 4 5 →