Highly sensitive sensing of DPA by lanthanide metal-organic frameworks and detection of fiber membranes

The detection of 2,6-pyridinecarboxylic acid (DPA), as a biomarker of Bacillus anthracis, has attracted wide attention. In previous reports of DPA detection, fluorescent probes may not have high specificity. Therefore, the rational design and development of fluorescent sensors with excellent performance is of great significance for the detection of DPA. In this study, two novel lanthanide metal-organic frameworks (Ln-MOFs) were synthesized by hydrothermal method using 3-polyfluorobiphenyl-3 ', 4,5 ' -tricarboxylic acid (H2FPTA) as ligand. Studies have shown that Ln-MOFs can detect DPA in real time, with detection limits of 0.54 mu M and 0.67 mu M, respectively, and have a high recovery rate (95 % -108 %) in fetal bovine serum. As a self-calibration sensor, other substances in the blood can be clearly distinguished by a two-dimensional fluorescence code diagram. After the Ln-MOFs were spun into nanofiber membranes, they responded quickly to DPA. This increases practicability and provides a promising idea for the development of simple and efficient ratio sensors.