Effects of Zishen Yutai Pills on in vitro Fertilization-Embryo Transfer Outcomes in Patients with Diminished Ovarian Reserve: A Prospective, Open-Labeled, Randomized and Controlled Study

被引:3
|
作者
Li, Xiu-fang [1 ,2 ]
Wang, Zhong-qing [3 ,4 ]
Xu, Hai-yan [2 ]
Liu, Hong [2 ]
Sheng, Yan [2 ]
Xu, Jin [2 ]
Li, Yuan-mei [2 ]
Lian, Fang [5 ]
机构
[1] Shandong Univ Tradit Chinese Med, Clin Coll 1, Jinan 250014, Peoples R China
[2] Shandong Univ, Ctr Reprod Med, Jinan 250021, Peoples R China
[3] Shandong Univ Tradit Chinese Med, Med Coll Optometry & Ophthalmol, Jinan 250014, Peoples R China
[4] Jinan Golden Time Hlth Nursing Hosp, Dept Tradit Chinese Med, Jinan 250000, Peoples R China
[5] Univ Tradit Chinese Med, Reprod & Genet Ctr Integrated Tradit & Western Med, Affiliated Hosp Shandong, Jinan 250011, Peoples R China
基金
中国国家自然科学基金;
关键词
Zishen Yutai Pills; diminished ovarian reserve; in vitro fertilization-embryo transfer; oocytes; embryos; FERTILITY; WOMEN;
D O I
10.1007/s11655-023-3546-y
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
ObjectiveTo explore the effects of Zishen Yutai Pills (ZYPs) on the quality of oocytes and embryos, as well as pregnancy outcomes in patients with diminished ovarian reserve (DOR) receiving in vitro fertilization-embryo transfer (IVF-ET). The possible mechanisms, involving the regulation of bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9), were also investigated.MethodsA total of 120 patients with DOR who underwent their IVF-ET cycle were randomly allocated to 2 groups in a 1:1 ratio. The patients in the treatment group (60 cases) received ZYPs from the mid-luteal phase of the former menstrual cycle by using gonadotropin-releasing hormone (GnRH) antagonist protocol. The patients in the control group (60 cases) received the same protocol but without ZYPs. The primary outcomes were the number of oocytes retrieved and high-quality embryos. Secondary outcomes included other oocyte or embryo indices as well as pregnancy outcomes. Adverse events were assessed by comparison of the incidence of ectopic pregnancy, pregnancy complications, pregnancy loss, and preterm birth. Contents of BMP15 and GDF9 in the follicle fluids (FF) were also quantified with enzyme-linked immunosorbent assay.ResultsCompared with the control group, the numbers of oocytes retrieved and high-quality embryos were significantly increased in the ZYPs group (both P<0.05). After treatment with ZYPs, a significant regulation of serum sex hormones was observed, including progesterone and estradiol. Both hormones were up-regulated compared with the control group (P=0.014 and 0.008), respectively. No significant differences were observed with regard to pregnancy outcomes including implantation rates, biochemical pregnancy rates, clinical pregnancy rates, live birth rates, and pregnancy loss rates (all P>0.05). The administration of ZYPs did not increase the incidence of adverse events. The expressions of BMP15 and GDF9 in the ZYPs group were significantly up-regulated compared with the control group (both P<0.05).ConclusionsZYPs exhibited beneficial effects in DOR patients undergoing IVF-ET, resulting in increments of oocytes and embryos, and up-regulation of BMP15 and GDF9 expressions in the FF. However, the effects of ZYPs on pregnancy outcomes should be assessed in clinical trials with larger sample sizes (Trial reqistration No. ChiCTR2100048441).
引用
收藏
页码:291 / 298
页数:8
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