3D vascularized eye tissue models age-related macular degeneration

被引：1
|
作者：
Song, Min Jae [1 ]
Bharti, Kapil [2 ]
机构：
[1] NCATS, NIH, Bethesda, MD 20892 USA
[2] NEI, NIH, Bethesda, MD USA
来源：
NATURE METHODS | 2023年 / 20卷 / 01期
关键词：
PERICYTES; CELLS;
D O I：
10.1038/s41592-022-01702-0
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
We engineered a 3D outer-blood-retina-barrier (3D-oBRB) with a fully polarized retinal pigment epithelium (RPE) monolayer on top of a Bruch's membrane and a fenestrated choriocapillaris network. This 3D-oBRB tissue faithfully recapitulates RPE- choriocapillaris interactions, dry age-related macular degeneration (AMD) phenotypes (including sub-RPE drusen deposits and choriocapillaris degeneration) and the wet AMD phenotype of choriocapillaris neovascularization.
引用
收藏
页码：46 / 47
页数：2
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