The Epigenetics of Neuropathic Pain: A Systematic Update

被引:1
|
作者
Petho, Gabor [1 ,2 ]
Kantas, Boglarka [1 ,3 ]
Horvath, Adam [2 ]
Pinter, Erika [1 ]
机构
[1] Univ Pecs, Med Sch, Dept Pharmacol & Pharmacotherapy, Sziget Str 12, H-7624 Pecs, Hungary
[2] Univ Pecs, Fac Pharm, Dept Pharmacol, Rokus Str 2, H-7624 Pecs, Hungary
[3] Univ Pecs, Dept Obstet & Gynecol, Edesanyak Str 17, H-7624 Pecs, Hungary
关键词
animal models; DNA methylation; epigenetics; histone acetylation; histone methylation; neuropathic pain; nociception; CHRONIC CONSTRICTION INJURY; PERIPHERAL-NERVE INJURY; DORSAL-HORN CONTRIBUTES; DNA METHYLATION; UP-REGULATION; HISTONE ACETYLATION; OPIOID RECEPTORS; SPINAL-CORD; RAT MODEL; MECHANICAL HYPERSENSITIVITY;
D O I
10.3390/ijms242417143
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Epigenetics deals with alterations to the gene expression that occur without change in the nucleotide sequence in the DNA. Various covalent modifications of the DNA and/or the surrounding histone proteins have been revealed, including DNA methylation, histone acetylation, and methylation, which can either stimulate or inhibit protein expression at the transcriptional level. In the past decade, an exponentially increasing amount of data has been published on the association between epigenetic changes and the pathomechanism of pain, including its most challenging form, neuropathic pain. Epigenetic regulation of the chromatin by writer, reader, and eraser proteins has been revealed for diverse protein targets involved in the pathomechanism of neuropathic pain. They include receptors, ion channels, transporters, enzymes, cytokines, chemokines, growth factors, inflammasome proteins, etc. Most work has been invested in clarifying the epigenetic downregulation of mu opioid receptors and various K+ channels, two types of structures mediating neuronal inhibition. Conversely, epigenetic upregulation has been revealed for glutamate receptors, growth factors, and lymphokines involved in neuronal excitation. All these data cannot only help better understand the development of neuropathic pain but outline epigenetic writers, readers, and erasers whose pharmacological inhibition may represent a novel option in the treatment of pain.
引用
收藏
页数:32
相关论文
共 50 条
  • [1] Update in neuropathic pain
    Baron, R.
    [J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 2009, 285 : S54 - S54
  • [2] Update on the pathobiology of neuropathic pain
    Niederberger, Ellen
    Kuehlein, Hilmar
    Geisslinger, Gerd
    [J]. EXPERT REVIEW OF PROTEOMICS, 2008, 5 (06) : 799 - 818
  • [3] Treatment of neuropathic pain: An update
    Attal, N.
    [J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 2019, 405
  • [4] Neuropathic pain A management update
    Votrubec, Milana
    Thong, Ian
    [J]. AUSTRALIAN FAMILY PHYSICIAN, 2013, 42 (03) : 92 - 96
  • [5] Epigenetics in Osteoarthritis Related Pain: An Update
    Villafane, Jorge Hugo
    Pedersini, Paolo
    Berjano, Pedro
    [J]. ARCHIVES OF RHEUMATOLOGY, 2020, 35 (03) : 456 - 457
  • [6] Neuropathic pain: update on treatment options
    Sommer, C.
    [J]. JOURNAL OF NEURAL TRANSMISSION, 2007, 114 (07) : CIII - CIII
  • [7] Update in the pharmacological treatment of neuropathic pain
    Alcantara Montero, A.
    Ibor Vidal, P. J.
    Alonso Verdugo, A.
    Trillo Calvo, E.
    [J]. MEDICINA DE FAMILIA-SEMERGEN, 2019, 45 (08): : 535 - 545
  • [8] Neuropathic Pain - Diagnostic and Therapeutic Update
    Arning, K.
    Baron, R.
    [J]. AKTUELLE NEUROLOGIE, 2008, 35 (10) : 519 - 525
  • [9] Trigeminal neuropathy and neuropathic pain - an update
    McMillan, R.
    [J]. ORAL DISEASES, 2014, 20 : 3 - 4
  • [10] Botulinum toxin A and neuropathic pain: An update
    Spagna, A.
    Attal, N.
    [J]. TOXICON, 2023, 232