Blood Pressure, Incident Cognitive Impairment, and Severity of CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study

被引：2

作者：

Babroudi, Seda ^{[1
,18
]}

Tighiouart, Hocine ^{[2
,3
]}

Schrauben, Sarah J. ^{[4
,5
]}

Cohen, Jordana B. ^{[4
,5
]}

Fischer, Michael J. ^{[6
,7
,8
]}

Rahman, Mahboob ^{[9
,10
]}

Hsu, Chi-yuan ^{[11
]}

Sozio, Stephen M. ^{[13
,14
]}

Weir, Matthew ^{[15
]}

Sarnak, Mark ^{[1
]}

Yaffe, Kristine ^{[12
]}

Tamura, Manjula Kurella ^{[16
,17
]}

Drew, David ^{[1
]}

机构：

[1] Tufts Med Ctr, William B Schwartz Div Nephrol, Boston, MA USA

[2] Tufts Med Ctr, Inst Clin Res & Hlth Policy Studies, Boston, MA USA

[3] Tufts Univ, Sch Med, Boston, MA USA

[4] Univ Penn, Perelman Sch Med, Dept Med, Philadelphia, PA USA

[5] Univ Penn, Perelman Sch Med, Dept Epidemiol Biostat & Informat, Philadelphia, PA USA

[6] Univ Illinois, Dept Med Nephrol, Chicago, IL USA

[7] Jesse Brown VA Med Ctr, Med Serv, Chicago, IL USA

[8] Edward J Hines VA Hosp, Ctr Innovat Complex Chron Healthcare CINCCH, Hines, IL USA

[9] Case Western Reserve Univ, Univ Hosp Cleveland, Med Ctr, Cleveland, OH USA

[10] Louis Stokes Cleveland VA Med Ctr, Cleveland, OH USA

[11] Div Nephrol, San Francisco, CA USA

[12] Univ Calif San Francisco, San Francisco, CA USA

[13] Johns Hopkins Univ, Sch Med, Dept Med, Div Nephrol, Baltimore, MD USA

[14] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[15] Univ Maryland, Sch Med, Div Nephrol, Baltimore, MD USA

[16] Stanford Univ, Sch Med, Div Nephrol, Palo Alto, CA USA

[17] VA Palo Alto Hlth Care Syst, Geriatr Res & Educ Clin Ctr, Palo Alto, CA USA

[18] Tufts Med Ctr, William B Schwartz Div Nephrol, 800 Washington St,Box 391, Boston, MA 02111 USA

来源：

AMERICAN JOURNAL OF KIDNEY DISEASES | 2023年 / 82卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Study Design: Longitudinal cohort study; CHRONIC KIDNEY-DISEASE; ASSOCIATION; DEMENTIA; ADULTS;

D O I：

10.1053/j.ajkd.2023.03.012

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Rationale & Objective: Hypertension is a known adults with chronic kidney disease. We sought to identify and characterize the relationship among blood pressure, cognitive impairment, and with chronic kidney disease. Setting & Participants: 3,768 participants in the Exposure: Baseline SBP and DBP were examined as exposure variables, using continuous (linear, per 10-mm Hg higher), categorical (SBP < 120 [reference], 120 to 140, > 140 mm Hg; DBP < 70 (reference), 70 to 80, > 80 mm Outcome: Incident cognitive impairment defined as a decline in Modified Mini-Mental State Examination (3MS) score to greater than 1 standard deviation below the cohort mean.

引用

页码：443 / 453.e1

页数：12

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