CD3+CD56+ and CD3-CD56+ lymphocytes in the cerebrospinal fluid of persons with HIV-1 subtypes B and C

被引：0
|
作者：
de Almeida, Sergio M. [1 ,4 ]
Beltrame, Miriam Perlingeiro [2 ]
Tang, Bin [3 ]
Rotta, Indianara [1 ]
Justus, Julie Lilian P. [2 ]
Schluga, Yara [2 ]
da Rocha, Maria Tadeu [2 ]
Martins, Edna [2 ]
Liao, Antony [3 ]
Abramson, Ian [3 ]
Vaida, Florin [3 ]
Schrier, Rachel [3 ]
Ellis, Ronald J. [3 ]
机构：
[1] Univ Fed Parana, Hosp Clin, Virol Lab, Curitiba, PR, Brazil
[2] Univ Fed Parana, Hosp Clin, Immunophenotyping Lab, Curitiba, PR, Brazil
[3] Univ Calif San Diego, HIV Neurobehav Res Ctr HNRC, San Diego, CA USA
[4] Complexo Hosp Clin UFPR, Seca Virol, Setor Analises Clin, Rua Padre Camargo 280, BR-80060240 Curitiba, PR, Brazil
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2023年 / 377卷
关键词：
Human immunodeficiency virus (HIV); HIV-1C; Natural killer (NK) cells; T lymphocytes with natural killer activity (NKT); Flow cytometry; Immunophenotyping; NATURAL-KILLER-CELLS; INNATE IMMUNE-RESPONSE; NK-CELLS; T-CELLS; PERIPHERAL-BLOOD; TAT PROTEIN; SUBSET DISTRIBUTION; MULTIPLE-SCLEROSIS; CYTOLYTIC FUNCTION; DISTINCT SUBSETS;
D O I：
10.1016/j.jneuroim.2023.578067
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The transactivator of transcription (Tat) is a HIV regulatory protein which promotes viral replication and chemotaxis. HIV-1 shows extensive genetic diversity, HIV-1 subtype C being the most dominant subtype in the world. Our hypothesis is the frequency of CSF CD3(+)CD56(+) and CD3(-)CD56(dim) is reduced in HIV-1C compared to HIV-1B due to the Tat C30S31 substitution in HIV-1C. 34 CSF and paired blood samples (PWH, n = 20; PWoH, n = 14) were studied. In PWH, the percentage of CD3(+)CD56(+) was higher in CSF than in blood (p < 0.001), comparable in both compartments in PWoH (p = 0.20). The proportion of CD3(-)CD56(dim) in CSF in PWH was higher than PWoH (p = 0.008). There was no subtype differences. These results showed CNS compartmentalization of NKT cell response in PWH.
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页数：13
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