Constructions and decoding of GC-balanced codes for edit errors

DNA -based storage has been a promising technique of data storage, due to its high density and long duration. During synthesizing and sequencing of DNA storage, edit errors including insertions, deletions and substitutions are introduced inevitably. An effective way to reduce the error probability is to limit the content of G and C in DNA sequences to around 50%, which is called GC -balanced. To deal with edit errors, DNA sequences are also expected to have error -correcting capabilities. In this paper, GC globally balanced and GC locally balanced error -correcting codes are explicitly constructed, respectively. Inspired by repetition codes, the proposed codes are able to correct multiple edit errors. Furthermore, an efficient decoding algorithm applied for both codes is derived when only one kind of edit error occur. (c) 2024 Elsevier Inc. All rights reserved.