Synthesis of benzo[b]thieno[2,3-c]quinolines via palladium-catalyzed ring-closing reaction

被引：1
|
作者：
Gabor, Dora [1 ]
Szabo, Timea [1 ]
Keglevich, Gyorgy [2 ]
Milen, Matyas [1 ]
机构：
[1] Egis Pharmaceut Plc, Directorate Drug Subst Dev, POB 100, H-1475 Budapest, Hungary
[2] Budapest Univ Technol & Econ, Dept Organ Chem & Technol, POB 91, H-1521 Budapest, Hungary
来源：
TETRAHEDRON LETTERS | 2023年 / 115卷
关键词：
Bezothieno[2; 3-c]quinolines; Kabachnik-Fields reaction; Ring closure; Intramolecular arylation;
D O I：
10.1016/j.tetlet.2022.154298
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Benzo[b]thieno[2,3-c]quinolines were synthesized via Pd-catalyzed ring closure reaction of the a- aminophosphonates obtained by the Kabachnik-Fields condensation of benzo[b]thiophene-2-carbox-aldehydes, 2-iodoanilines and diethyl phosphite or dibenzyl phosphite. The intramolecular cyclizations remained incomplete under the conditions applied. The products were isolated in 11-42% yields, and the unreacted starting materials were recovered from the reaction mixture.(c) 2022 Elsevier Ltd. All rights reserved.
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页数：6
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