Meeting report of the 4th European biotransformation workshop

被引：0

作者：

Walles, M. ^{[1
,5
]}

Pahler, A. ^{[2
]}

Isin, E. M. ^{[3
]}

Ahlqvist, Marie M. ^{[4
]}

机构：

[1] Pharmacokinet Sci, Biomed Res, Novartis, Basel, Switzerland

[2] F Hoffmann La Roche AG Res & Dev Div, Pharm Res & Early Dev, Basel, Switzerland

[3] DMPK, Translat Med, Paris Saclay, France

[4] Drug Metab & Pharmacokinet Res & Early Dev Cardiov, Drug Metab & Pharmacokinet Res & Early Dev Cardiov, AstraZeneca, Gothenburg, Sweden

[5] Novartis, Biomed Res, Fabrikstr 14 1-10-02,Novartis Campus, CH-4052 Basel, Switzerland

来源：

XENOBIOTICA | 2024年 / 54卷 / 05期

关键词：

Unusual biotransformation reactions; Mass-MetaSite; biotransformation softwares; AMS; F-NMR for metabolite profiling; LC-ICP-MS for metabolite profiling; INHIBITORS;

D O I：

10.1080/00498254.2024.2302547

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Challenges, strategies and new technologies in the field of biotransformation were presented and discussed at the fourth European Biotransformation Workshop which was held in collaboration with the joint ISSX/DMDG meeting on June 15, 2023 at the University of Hertfordshire in Hatfield, UK. 2. In this meeting report we summarise the presentations and discussions from this workshop. 3. The topics covered are listed below: Unusual biotransformation reactions Biotransformation Workflows in Discovery utilising various softwares for structure elucidation Biotransformation software for the identification of peptide metabolites Accelerator Mass Spectrometry (AMS) for endogenous and xenobiotic metabolite profiling Metabolite profiling using quantitative Nuclear magnetic resonance (NMR) and liquid chromatography coupled to inductively coupled plasma-mass spectrometry (LC-ICP-MS)

引用

页码：257 / 262

页数：6

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