Polymer Delivery Systems for Long-Acting Antiretroviral Drugs

被引：3
|
作者：
Nayan, Mohammad Ullah [1 ]
Panja, Sudipta [1 ]
Sultana, Ashrafi [1 ]
Zaman, Lubaba A. [1 ]
Vora, Lalitkumar K. [2 ]
Sillman, Brady [1 ]
Gendelman, Howard E. [1 ]
Edagwa, Benson [1 ]
机构：
[1] Univ Nebraska Med Ctr, Dept Pharmacol & Expt Neurosci, Omaha, NE 68198 USA
[2] Queens Univ Belfast, Med Biol Ctr, Sch Pharm, Belfast BT9 7BL, North Ireland
来源：
PHARMACEUTICS | 2024年 / 16卷 / 02期
基金：
美国国家卫生研究院;
关键词：
long-acting formulations; polymer; antiretroviral therapy; HIV; chronic infectious diseases; implants; vaginal rings; prodrug nanoformulations; microarray patches; ETHYLENE-VINYL ACETATE; DAPIVIRINE VAGINAL RING; ELVITEGRAVIR LOADED NANOPARTICLES; POLYURETHANE INTRAVAGINAL RINGS; TENOFOVIR DISOPROXIL FUMARATE; IN-VITRO DEGRADATION; CONTROLLED-RELEASE; EPSILON-CAPROLACTONE; POLYVINYL-ALCOHOL; BIODEGRADABLE POLYMERS;
D O I：
10.3390/pharmaceutics16020183
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The success of long-acting (LA) drug delivery systems (DDSs) is linked to their biocompatible polymers. These are used for extended therapeutic release. For treatment or prevention of human immune deficiency virus type one (HIV-1) infection, LA DDSs hold promise for improved regimen adherence and reduced toxicities. Current examples include Cabenuva, Apretude, and Sunlenca. Each is safe and effective. Alternative promising DDSs include implants, prodrugs, vaginal rings, and microarray patches. Each can further meet patients' needs. We posit that the physicochemical properties of the formulation chemical design can optimize drug release profiles. We posit that the strategic design of LA DDS polymers will further improve controlled drug release to simplify dosing schedules and improve regimen adherence.
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页数：41
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