Roles of Hippo-YAP/TAZ signalling in intervertebral disc degeneration

被引：2
|
作者：
Shi, Zheng-wei [1 ]
Tuo, Yuan [1 ]
Feng, Chao-shuai [1 ]
Zhu, Lei [1 ]
Song, Zong-rang [1 ]
Liu, Tuan-jiang [1 ]
Hao, Ding-jun [1 ]
机构：
[1] Xi An Jiao Tong Univ, Hong Hui Hosp, Coll Med, Dept Spine Surg, Xian 710054, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 159卷
基金：
中国国家自然科学基金;
关键词：
Hippo signalling; Intervertebral disc; YAP/TAZ; Degeneration; PATHWAY; YAP; DROSOPHILA; BIOLOGY; GROWTH; PHOSPHORYLATION; DISORDERS; MUTATIONS; AUTOPHAGY; ENCODES;
D O I：
10.1016/j.biopha.2022.114099
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Intervertebral disc degeneration (IVDD), a common cartilage-degenerative disease, is considered the main cause of low back pain (LBP). Owing to the complex aetiology and pathophysiology of IVDD, its molecular mechanisms and definitive treatment of IVDD remain unclear. As an evolutionarily and functionally conserved signalling pathway, Hippo-YAP/TAZ signalling plays a crucial role in IVDD progression. In this review, we discuss the regulation of Hippo-YAP/TAZ signalling and summarise the recent research progress on its role in cartilage homeostasis and IVDD. We also discuss the current application and future prospects of IVDD treatments based on Hippo-YAP/TAZ signalling.
引用
收藏
页数：7
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