Pleiotropic effects of Salacia reticulata and Simvastatin on oxidative stress and insulin resistance in a rat model

被引：0
|
作者：
Gujjala, Sudhakara [1 ]
Bangeppagari, Manjunatha [2 ]
Devarakonda, Venkata Lakshmi Narasimha Prasad [3 ]
Bellamkonda, Ramesh [4 ]
Bhadramraju, Ramu [1 ]
Kameswaran, Srinivasan [5 ]
Ramaswamy, Rajendran [6 ]
Desireddy, Saralakumari [1 ]
机构：
[1] Sri Krishnadevaraya Univ, Dept Biochem, Ananthapuram, Andhra Pradesh, India
[2] Sri Devaraj Urs Acad Higher Educ & Res, Dept Cell Biol & Mol Genet, Kolar 563103, Karnataka, India
[3] Sri Devaraj Urs Acad Higher Educ & Res, Kolar 563103, Karnataka, India
[4] Vikrama Simhapuri Univ, Dept Food Technol, SPSR Nellore, Andhra Pradesh, India
[5] Vikrama Simhapuri Univ Coll, Dept Bot, Nellore, Andhra Pradesh, India
[6] Green Chem Herbal Extract & Formulat, Bangalore, India
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 164卷
关键词：
Salacia reticulata; High-fat diet; Oxidative stress; Insulin resistance; Metabolic syndrome; HIMBUTU AQUEOUS EXTRACT; CARALLUMA-FIMBRIATA; LIVER; ACCUMULATION; MIXTURE; OBESITY; INJURY;
D O I：
10.1016/j.biopha.2023.114960
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Background: The present study investigated the effects of Salacia reticulata and simvastatin on oxidative stress and insulin resistance in Sprague-Dawley (SD) rats. We compared the protective effect of a methanolic extract of Salacia reticulata (SR) with simvastatin (SVS) in rats fed a high-fat diet (HFD). Methods and results: Male Sprague-Dawley rats were divided into the following five different groups: control (C), C+SR, HFD, HFD+SR, and HFD+SVS. High-fat diet fed rats showed hyperglycemia, hyperinsulinemia, hyperleptinemia, dyslipidemia, and hypoadiponectinemia after 90 days. Treatment of high-fat diet fed rats with SR/ SVS significantly (p < 0.05) reduced high-fat diet induced increases in plasma triglycerides, total cholesterol, very-low-density lipoprotein (VLDL), low-density lipoprotein (LDL) and decreased high- density lipoprotein (HDL) accompanied by an increase in lipid peroxidation (LPO) and protein oxidation. In addition, a significant decrease in the activities of antioxidant enzymes and enzymes of the polyol pathway was observed in rats fed high-fat diet. SR was found to be more effective than SVS. Moreover, infiltration of inflammatory cells and fibrosis in the liver of high-fat diet fed rats by SR/SVS were also prevented. Conclusions: The present study confirms that SR/SVS may be a new and promising remedial approach because of its beneficial effects on the pathophysiological processes of obesity and related metabolic disorders.
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页数：12
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