Chemical Strategies towards the Development of Effective Anticancer Peptides

被引:0
|
作者
Li, Cuicui [1 ]
Jin, Kang [1 ]
机构
[1] Shandong Univ, Cheeloo Coll Med, Sch Pharm, Dept Med Chem,Key Lab Chem Biol,Minist Educ, Jinan 250012, Shandong, Peoples R China
基金
中国国家自然科学基金;
关键词
Anticancer peptide; ACPs; cytotoxicity; drug resistance; undruggable proteins; chemotherapy; CELL-PENETRATING PEPTIDE; PHAGE DISPLAY TECHNOLOGY; STRUCTURE-BASED DESIGN; BREAST-CANCER CELLS; BIOLOGICAL EVALUATION; WEB SERVER; PHASE-I; PROTEOLYTIC STABILITY; ANTITUMOR-ACTIVITY; AMINO-ACIDS;
D O I
10.2174/0929867330666230426111157
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cancer is increasingly recognized as one of the primary causes of death and has become a multifaceted global health issue. Modern medical science has made significant advancements in the diagnosis and therapy of cancer over the past decade. The detrimental side effects, lack of efficacy, and multidrug resistance of conventional cancer therapies have created an urgent need for novel anticancer therapeutics or treatments with low cytotoxicity and drug resistance. The pharmaceutical groups have recognized the crucial role that peptide therapeutic agents can play in addressing unsatisfied healthcare demands and how these become great supplements or even preferable alternatives to biological therapies and small molecules. Anticancer peptides, as a vibrant therapeutic strategy against various cancer cells, have demonstrated incredible anticancer potential due to high specificity and selectivity, low toxicity, and the ability to target the surface of traditional "undruggable" proteins. This review will provide the research progression of anticancer peptides, mainly focusing on the discovery and modifications along with the optimization and application of these peptides in clinical practice.
引用
收藏
页码:1839 / 1873
页数:35
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