Numerical study on biomechanics in bifurcated coronary artery with plaques of different scenarios considering cardiac motion

During the development of atherosclerosis, plaques of different scenarios are formed at the bifurcation of the coronary arteries, which causes patients to exhibit different symptoms. The purpose of this study was to analyze the effect of plaque in different scenarios on the biomechanics of the bifurcated left coronary artery. In order to reflect the blood flow in the atherosclerotic coronary arteries more exactly, five vivid coronary artery models with a plaque of different scenarios are created based on Computed Tomography (CT) and anatomical images. Furthermore, the three-dimensional artery motion equations are created and fitted to the distal end of the coronary artery to describe the cardiac motion. The reciprocal influence of fluid and solid is also taken into account, constituting a fluid-structure interaction study. The risk of plaques in different scenarios was assessed by analyzing different physical parameters of arteries and blood. The results show that the effect of plaque on arterial stress is concentrated in the proximal coronary artery while the impact on blood flow is mainly focused on the narrow area and downstream of plaque. Wall shear stress promotes plaque growth in the early stages of atherosclerosis and drives plaque rupture after stenosis formation. There is a negative correlation between relative residence time and the degree of coronary artery stenosis and stiffness.