Copper-Catalyzed Synthesis of Masked (Hetero)Aryl Sulfinates

被引：0

作者：

Merino, May R. ^{[1
]}

Cook, Xinlan A. F. ^{[1
]}

Blakemore, David C. ^{[2
]}

Moses, Ian B. ^{[3
]}

Sach, Neal W. ^{[4
]}

Shavnya, Andre ^{[2
]}

Willis, Michael C. ^{[1
]}

机构：

[1] Univ Oxford, Dept Chem, Oxford OX1 3TA, England

[2] Pfizer Inc, Med Design, Groton, CT 06340 USA

[3] Pfizer Inc, Pharmaceut Sci, Kent CT13 9ND, England

[4] Pfizer Inc, La Jolla Labs, Med Design, San Diego, CA 92121 USA

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 14期

基金：

英国工程与自然科学研究理事会;

关键词：

NUCLEOPHILIC COUPLING PARTNERS; DESULFITATIVE ARYLATION; CONVENIENT SYNTHESIS; SULFUR-DIOXIDE; REAGENT; BROMIDES;

D O I：

10.1021/acs.orglett.3c03621

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Catalysis using substoichiometric copper facilitates the synthesis of masked (hetero)aryl sulfinates under mild, base-free conditions from aryl iodides and the commercial sulfonylation reagent sodium 1-methyl 3-sulfinopropanoate (SMOPS). The development of a tert-butyl ester variant of the SMOPS reagent allowed the use of aryl bromide substrates. The sulfones thus generated can be unmasked and functionalized in situ to form a variety of sulfonyl-containing functional groups.

引用

页码：2817 / 2820

页数：4

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