Synthesis Of Dipyrrolobenzo[1,2-a: 2′,1′-c][1,4]diazepine Scaffold Via Three-Component Reaction

被引：0

作者：

Zinoveva, Anna D. ^{[1
]}

Borisova, Tatiana N. ^{[1
]}

Podchufarova, Valeria A. ^{[1
]}

Novikov, Anton P. ^{[2
]}

Romanycheva, Anna A. ^{[3
]}

Shetnev, Anton A. ^{[4
]}

Titov, Alexander A. ^{[1
]}

Varlamov, Alexey V. ^{[1
]}

Voskressensky, Leonid G. ^{[1
]}

机构：

[1] RUDN Univ, Peoples Friendship Univ Russia, Organ Chem Dept, 6 Miklukho Maklaya St, Moscow 117198, Russia

[2] Russian Acad Sci, Frumkin Inst Phys Chem & Electrochem, 31 Leninsky Prosp,Bld 4, Moscow 119071, Russia

[3] Yaroslavl State Pedagogial Univ, Dept Chem Dev, 108 Respublikanskaya St, Yaroslavl 150000, Russia

[4] Moscow Inst Phys & Technol, Inst Skiy Per 9, Dolgoprudnyi 141701, Moscow Region, Russia

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 13卷 / 05期

关键词：

domino reaction; electron-deficient alkenes; indolizino[8,7-b]indoles; pyrrolo[1,2-a][1,4]benzodiazepines; zwitterion; AGENTS; PYRROLOBENZODIAZEPINES; DERIVATIVES;

D O I：

10.1002/ajoc.202400010

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A three component reaction employing readily available starting materials: 2-(1-pyrrolyl)benzylamine, arylglyoxal monohydrates and electron-deficient alkenes in the synthesis of dipyrrolobenzo[1,2-a : 2 ',1 '-c][1,4]diazepines - previously undescribed system and indolo[2,1-c]pyrrolo[1,2-a][1,4]benzodiazepine derivatives have been shown. Domino reactions of pyrrolo[1,2-a][1,4]benzodiazepines with electron-deficient alkenes has been proposed as another approach. The applicability of the three-component reaction for the synthesis of indolizino[8,7-b]indole derivatives from tryptamine has been studied. The in vitro biological activity of title compounds has been tested.

引用

页数：6

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