Immunotherapeutic Approaches for the Treatment of Glioblastoma Multiforme: Mechanism and Clinical Applications

被引：2

作者：

Das, Suprava ^{[1
]}

Dash, Banendu Sunder ^{[1
]}

Premji, Thejas P. ^{[1
]}

Chen, Jyh-Ping ^{[1
,2
,3
,4
,5
]}

机构：

[1] Chang Gung Univ, Dept Chem & Mat Engn, Taoyuan 33302, Taiwan

[2] Chang Gung Mem Hosp Linkou, Dept Neurosurg, Taoyuan 33305, Taiwan

[3] Chang Gung Mem Hosp Linkou, Craniofacial Res Ctr, Taoyuan 33305, Taiwan

[4] Chang Gung Univ Sci & Technol, Coll Human Ecol, Res Ctr Food & Cosmet Safety, Taoyuan 33305, Taiwan

[5] Ming Chi Univ Technol, Dept Mat Engn, New Taipei City 24301, Taiwan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 13期

关键词：

glioblastoma multiforme; brain cancer; clinical application; immunotherapy; NEWLY-DIAGNOSED GLIOBLASTOMA; IMMUNE CHECKPOINT BLOCKADE; T-CELL IMMUNOGLOBULIN; REPORT PRIMARY BRAIN; CANCER-IMMUNOTHERAPY; PD-L1; EXPRESSION; DENDRITIC CELLS; MUCIN DOMAIN-3; UNITED-STATES; OPEN-LABEL;

D O I：

10.3390/ijms241310546

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glioma is one of the most aggressive types of primary brain tumor with a high-grade glioma known as glioblastoma multiforme (GBM). Patients diagnosed with GBM usually have an overall survival rate of less than 18 months after conventional therapy. This bleak prognosis underlines the need to consider new therapeutic interventions for GBM treatment to overcome current treatment limitations. By highlighting different immunotherapeutic approaches currently in preclinical and clinical trials, including immune checkpoint inhibitors, chimeric antigen receptors T cells, natural killer cells, vaccines, and combination therapy, this review aims to discuss the mechanisms, benefits, and limitations of immunotherapy in treating GBM patients.

引用

页数：26

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