Solubility Enhancement of Carvedilol by Solid Dispersion Technique Using Sodium Alginate, Guar Gum, Xanthan Gum, and Locust Bean Gum as Polymers

被引:0
|
作者
Sopyan, Iyan [1 ]
Adiningsih, Nurdiani [1 ]
Megantara, Sandra [2 ]
Marvita, Siska Sari [1 ]
机构
[1] Padjadjaran State Univ, Fac Pharm, Dept Pharmaceut & Pharmaceut Technol, Jl Bandung Sumedang KM 21, Sumedang 45363, W Java, Indonesia
[2] Padjadjaran State Univ, Fac Pharm, Dept Pharmaceut Anal & Med Chem, Jl Bandung Sumedang KM 21, Sumedang 45363, W Java, Indonesia
关键词
carvedilol; BCS class II; solid dispersion; DISSOLUTION RATE; CARRIER;
D O I
10.22146/ijc.77698
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Carvedilol (CVD) is a non-selective beta-blocker. CVD is included in BCS class II. It has low water solubility. In this research, solid dispersion was used to increase the solubility and dissolution profile of CVD. In silico study using the ligand-ligand docking method. The preparation of solid dispersion using the kneading method with a weight ratio of 1:1, 1:2, 1:3, and 1:4, evaluation of solid dispersion includes solubility and dissolution. The best solid dispersion was characterized using FTIR, DSC, and PXRD. In silico study showed complexes CVD-SA, CVD-GG, CVD-XG and CVD-LBG have a hydrogen interaction. SA and XG were chosen as carriers in solid dispersion. CVD solid dispersion showed increased solubility in all samples, with the highest increase at 90.63 times at CVD: XG (1:4). The results of the dissolution profile obtained at 60 min are 64.95 +/- 0.45% at pure CVD, 83.32 +/- 1.19% at CVD:SA (1:4), and 72.56 +/- 3.62% at CVD: XG (1:4). The FTIR spectrum indicates an interaction between CVD and SA. The thermogram indicated the amorphous drug, and the diffractogram showed a decrease in crystallinity. Solid dispersion is proven to increase the solubility and dissolution profile of CVD. Solid dispersion CVD: SA (1:4) showed the highest solubility and dissolution profile.
引用
收藏
页码:349 / 357
页数:9
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