Treatment of status epilepticus: Physiology, pharmacology, and future directions

被引：4
|
作者：
Sankar, Raman [1 ,2 ,3 ]
机构：
[1] Univ Calif Los Angeles, Dept Neurol, David Geffen Sch Med, Los Angeles, CA USA
[2] Univ Calif Los Angeles, Dept Pediat, David Geffen Sch Med, Los Angeles, CA USA
[3] Univ Calif Los Angeles, UCLA Ctr Hlth Sci, David Geffen Sch Med, 22 474 MDCC,10833 Conte Ave, Los Angeles, CA 90095 USA
来源：
EPILEPSIA OPEN | 2023年 / 8卷
关键词：
antiseizure medications; extrasynaptic modulation; postsynaptic modulation; presynaptic modulation; status epilepticus; REFRACTORY STATUS EPILEPTICUS; SUSTAINING STATUS EPILEPTICUS; GABA(A) RECEPTORS; ANTIEPILEPTIC DRUGS; PYRAMIDAL NEURONS; HIGH-AFFINITY; TRAFFICKING; INHIBITION; KETAMINE; GALANIN;
D O I：
10.1002/epi4.12725
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The review presents retrospective, present views and future perspectives on the treatment of status epilepticus (SE). First, presynaptic, postsynaptic, and extrasynaptic mechanisms underlying sustaining ongoing seizure activity are highlighted. Next, mechanism-based choices of antiseizure medications capable of promptly arresting SE are introduced. Finally, challenges associated with translating the advances in laboratory research in clinical practice are discussed.
引用
收藏
页码：S141 / S148
页数：8
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