Clinical outcome of testosterone supplementation assessed by andropausal male symptom scores in type 2 diabetes testosterone- deficient patients receiving testosterone compared to those not receiving testosterone: A nested case-control study

Background and aims: This study aimed to explore the proportion of andropause in male patients with type 2 diabetes using an aging male symptoms scale and assess the clinical outcome of testosterone supplementation in patients with deficient testosterone levels at a tertiary care hospital.Methods: Male patients with diabetes and total serum testosterone levels (& LE;12 nmol/L) were included in the study. Patients with testosterone supplementation, the standard of care among testosterone-deficient male patients, were included in the study (n = 35). Those not exposed to testosterone sup-plementation were considered controls (n = 35) and reassessed over 14 weeks for aging male symptom scores (AMS).Results: The prevalence of andropause among the participants was 11% (117/1057). Data was analyzed as per protocol analysis. Exposure group had a frequency of 25.80%, and 19.35% in moderate and severe symptoms of AMS scores. Non-exposure group had frequency of 26.66% and 23.34% in moderate and severe symptoms of AMS scores. A significant mean difference (t =-2.93, P-value <0.05) was noted between exposure and non-exposure to testosterone supplementation.Conclusion: Results concluded that andropause is prevalent in patients with type 2 diabetes and low testosterone levels. Testosterone therapy affects aging andropausal symptoms such as the feeling of general well-being, joint pain and muscular ache, sleep problems, anxiety, and libido among patients with type 2 diabetes.& COPY; 2023 Published by Elsevier Ltd on behalf of Research Trust of DiabetesIndia (DiabetesIndia) and National Diabetes Obesity and Cholesterol Foundation (N-DOC).