Utilization of Functionalized Metal-Organic Framework Nanoparticle as Targeted Drug Delivery System for Cancer Therapy

被引：23
|
作者：
Tran, Vy Anh [1 ,2 ]
Thuan Le, Van [3 ,4 ]
Doan, Van Dat [5 ]
Vo, Giang N. L. [6 ]
机构：
[1] Nguyen Tat Thanh Univ, Inst Appl Technol & Sustainable Dev, Ho Chi Minh City 700000, Vietnam
[2] Nguyen Tat Thanh Univ, Fac Environm & Food Engn, Ho Chi Minh City 700000, Vietnam
[3] Duy Tan Univ, Inst Res & Dev, Ctr Adv Chem, 03 Quang Trung, Da Nang 550000, Vietnam
[4] Duy Tan Univ, Fac Nat Sci, 03 Quang Trung, Da Nang 550000, Vietnam
[5] Ind Univ Ho Chi Minh City, Fac Chem Engn, Ho Chi Minh City 700000, Vietnam
[6] Univ Med & Pharm Ho Chi Minh City, Fac Pharm, Ho Chi Minh City 700000, Vietnam
来源：
PHARMACEUTICS | 2023年 / 15卷 / 03期
关键词：
metal-organic frameworks; targeting drug delivery; targeted cancer therapy; light response; multi-targeted response; NANOSCALE COORDINATION POLYMERS; ONE-POT SYNTHESIS; CONTROLLED-RELEASE; MOF NANOPARTICLES; CLONAL EVOLUTION; IN-VITRO; PLATFORM; CARBON; DOXORUBICIN; IMMUNE;
D O I：
10.3390/pharmaceutics15030931
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Cancer is a multifaceted disease that results from the complex interaction between genetic and environmental factors. Cancer is a mortal disease with the biggest clinical, societal, and economic burden. Research on better methods of the detection, diagnosis, and treatment of cancer is crucial. Recent advancements in material science have led to the development of metal-organic frameworks, also known as MOFs. MOFs have recently been established as promising and adaptable delivery platforms and target vehicles for cancer therapy. These MOFs have been constructed in a fashion that offers them the capability of drug release that is stimuli-responsive. This feature has the potential to be exploited for cancer therapy that is externally led. This review presents an in-depth summary of the research that has been conducted to date in the field of MOF-based nanoplatforms for cancer therapeutics.
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页数：30
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