How to improve the outcomes of elderly acute myeloid leukemia patients through allogeneic hematopoietic stem cell transplantation

被引：1
|
作者：
Jiang, Shan [1 ]
Yan, Han [1 ]
Lu, Xuan [1 ]
Wei, Ruowen [1 ]
Chen, Haoran [1 ]
Zhang, Ao [1 ]
Shi, Wei [1 ]
Xia, Linghui [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Hematol, Wuhan, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
关键词：
acute myeloid leukaemia (AML); elderly patients; allogeneic hematopoietic cell transplantation; conditioning regimen; GvHD; relapse; VERSUS-HOST-DISEASE; COMPREHENSIVE GERIATRIC ASSESSMENT; RECEIVING INDUCTION CHEMOTHERAPY; HUMAN HERPESVIRUS-6 ENCEPHALITIS; ACUTE MYELOGENOUS LEUKEMIA; DONOR LYMPHOCYTE INFUSION; INVASIVE FUNGAL DISEASES; LONG-TERM SURVIVORS; RISK ACUTE-LEUKEMIA; OLDER-ADULTS;
D O I：
10.3389/fimmu.2023.1102966
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In recent years, with the gradual advancement of haploidentical transplantation technology, the availability of donors has increased significantly, along with the widespread use of reduced-intensity conditioning and the improvement of nursing techniques, giving more elderly acute myeloid leukemia (AML) patients the chance to receive allogeneic hematopoietic stem cell transplantation. We have summarized the classic and recently proposed pre-transplant assessment methods and assessed the various sources of donors, conditioning regimens, and post-transplant complication management based on the outcomes of large-scale clinical studies for elderly AML patients.
引用
收藏
页数：14
相关论文
共 50 条
  • [1] OUTCOMES OF ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION IN PATIENTS WITH ACUTE MYELOID LEUKEMIA IN THIRD REMISSION
    Beitinjaneh, A.
    Jakob, J.
    Saliba, R.
    Chen, J.
    Rondon, G.
    Giralt, S.
    Cortes, J. E.
    Champlin, R.
    De Lima, M.
    [J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2012, 18 (02) : S328 - S328
  • [2] Allogeneic hematopoietic stem cell transplantation in elderly patients with acute myeloid leukemia: A single center experience
    Ilhan, O.
    Yavuz, G.
    Seval, G. Cengiz
    Bozdag, S. Civriz
    Yuksel, M. Kurt
    Topcuoglu, P.
    Arslan, O.
    Ozcan, M.
    Demirer, T.
    Gurman, G.
    Beksac, M.
    [J]. BONE MARROW TRANSPLANTATION, 2022, 57 (SUPPL 1) : 125 - 125
  • [3] Current Status and Perspectives of Allogeneic Hematopoietic Stem Cell Transplantation in Elderly Patients with Acute Myeloid Leukemia
    Sophie, Servais
    Yves, Beguin
    Frederic, Baron
    [J]. STEM CELLS TRANSLATIONAL MEDICINE, 2022, 11 (05) : 461 - 477
  • [4] Allogeneic Hematopoietic Stem Cell Transplantation for Older Patients With Acute Myeloid Leukemia
    Levin-Epstein, Rebecca
    Oliai, Caspian
    Schiller, Gary
    [J]. CURRENT TREATMENT OPTIONS IN ONCOLOGY, 2018, 19 (12)
  • [5] Allogeneic Hematopoietic Stem Cell Transplantation for Older Patients With Acute Myeloid Leukemia
    Rebecca Levin-Epstein
    Caspian Oliai
    Gary Schiller
    [J]. Current Treatment Options in Oncology, 2018, 19
  • [6] Outcomes of Second Allogeneic Hematopoietic Cell Transplantation for Patients With Acute Myeloid Leukemia
    Yalniz, Fevzi F.
    Saliba, Rima M.
    Greenbaum, Uri
    Ramdial, Jeremy
    Popat, Uday
    Oran, Betul
    Alousi, Amin
    Olson, Amanda
    Alatrash, Gheath
    Marin, David
    Rezvani, Katayoun
    Hosing, Chitra
    Im, Jin
    Mehta, Rohtesh
    Qazilbash, Muzaffar
    Joseph, Jacinth Joy
    Rondon, Gabriela
    Kanagal-Shamanna, Rashmi
    Shpall, Elizabeth
    Champlin, Richard
    Kebriaei, Partow
    [J]. TRANSPLANTATION AND CELLULAR THERAPY, 2021, 27 (08): : 689 - 695
  • [7] Outcomes of Second Allogeneic Hematopoietic Cell Transplantation for Patients with Acute Myeloid Leukemia
    Yalniz, Fevzi
    Saliba, Rima
    Greenbaum, Uri
    Ramdial, Jeremy
    Alousi, Amin
    Joseph, Jacinth
    Olson, Amanda
    Alatrash, Gheath
    Marin, David
    Rezvani, Katayoun
    Hosing, Chitra
    Im, Jin
    Shpall, Elizabeth
    Mehta, Rohtesh
    Qazilbash, Muzaffar
    Popat, Uday
    Oran, Betul
    Champlin, Richard
    Kebriaei, Partow
    [J]. CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2020, 20 : S202 - S202
  • [8] Impact of age on outcomes of allogeneic hematopoietic stem cell transplantation with reduced intensity conditioning in elderly patients with acute myeloid leukemia
    Aoki, Jun
    Kanamori, Heiwa
    Tanaka, Masatsugu
    Yamasaki, Satoshi
    Fukuda, Takahiro
    Ogawa, Hiroyasu
    Iwato, Koji
    Ohashi, Kazuteru
    Okumura, Hirokazu
    Onizuka, Makoto
    Maesako, Yoshitomo
    Teshima, Takanori
    Kobayashi, Naoki
    Morishima, Yasuo
    Hirokawa, Makoto
    Atsuta, Yoshiko
    Yano, Shingo
    Takami, Akiyoshi
    [J]. AMERICAN JOURNAL OF HEMATOLOGY, 2016, 91 (03) : 302 - 307
  • [9] Real-World Outcomes Among Elderly Acute Myeloid Leukemia Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
    Medeiros, Bruno C.
    Satram-Hoang, Sacha
    Hoang, Khang Q.
    Momin, Faiyaz
    Hurst, Deborah
    Reyes, Carolina
    [J]. BLOOD, 2014, 124 (21)
  • [10] Allogeneic hematopoietic stem cell transplantation in elderly patients with acute myeloid leukemia or myelodysplastic syndromes: myth and reality
    A. Sutra Del Galy
    A. Marouf
    E. Raffoux
    M. Robin
    D. Michonneau
    M. Sébert
    F. Sicre de Fontebrune
    A. Xhaard
    E. Lengline
    R. Itzykson
    C. Frieri
    H. Dombret
    P. Fenaux
    R. Peffault de Latour
    L. Adès
    G. Socié
    [J]. Leukemia, 2021, 35 : 225 - 228
12345