Sotrovimab Resistance and Viral Persistence After Treatment of Immunocompromised Patients Infected With the Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant

被引：28
|
作者：
Huygens, Sammy [1 ,2 ]
Munnink, Bas Oude [3 ]
Gharbharan, Arvind [1 ,2 ]
Koopmans, Marion [3 ]
Rijnders, Bart [1 ,2 ]
机构：
[1] Erasmus MC, Univ Med Ctr, Dept Internal Med, Sect Infect Dis, Rotterdam, Netherlands
[2] Erasmus MC, Univ Med Ctr, Dept Med Microbiol & Infect Dis, Rotterdam, Netherlands
[3] Erasmus MC, Univ Med Ctr, Dept Virosci, Rotterdam, Netherlands
来源：
CLINICAL INFECTIOUS DISEASES | 2023年 / 76卷 / 03期
关键词：
SARS-CoV-2; Omicron; sotrovimab; resistance; immunocompromised;
D O I：
10.1093/cid/ciac601
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Viral evolution was evaluated in 47 immunocompromised patients treated with sotrovimab. Sequencing of SARS-CoV-2 following therapy was successful in 16. Mutations associated with sotrovimab resistance were documented in 6; viral replication continued after 30 days in 5. Combination antibody therapy may be required to avoid acquired resistance in immunocompromised patients.
引用
收藏
页码：E507 / E509
页数：3
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