Utility of triazole antifungal therapeutic drug monitoring: Insights from the Society of Infectious Diseases Pharmacists Endorsed by the Mycoses Study Group Education and Research Consortium

被引：17

作者：

McCreary, Erin K. K. ^{[1
]}

Davis, Matthew R. R.

Narayanan, Navaneeth ^{[2
]}

Andes, David R. R. ^{[3
,4
]}

Cattaneo, Dario ^{[5
]}

Christian, Robbie ^{[6
]}

Lewis, Russell E. E. ^{[7
]}

Watt, Kevin M. M. ^{[8
,9
]}

Wiederhold, Nathan P. P. ^{[10
]}

Johnson, Melissa D. D. ^{[11
]}

机构：

[1] Univ Pittsburgh, Dept Med, Div Infect Dis, Sch Med, Pittsburgh, PA USA

[2] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Pharm Practice & Adm, Piscataway, NJ USA

[3] Univ Wisconsin, Dept Med, Madison, WI USA

[4] Univ Wisconsin, Dept Med Microbiol & Immunol, Madison, WI USA

[5] Luigi Sacco Univ Hosp, Dept Lab Med, Unit Clin Pharmacol, Milan, Italy

[6] Vet Affairs Northeast Ohio Healthcare Syst, Dept Pharm, Cleveland, OH USA

[7] Univ Padua, Dept Mol Med, Padua, Italy

[8] Univ Utah, Div Pediat Clin Pharmacol, Salt Lake City, UT USA

[9] Univ Utah, Div Crit Care, Salt Lake City, UT USA

[10] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol & Lab Med, Fungus Testing Lab, San Antonio, TX USA

[11] Duke Univ, Dept Med, Div Infect Dis, Med Ctr, Duke Box 102359, Durham, NC 27710 USA

来源：

PHARMACOTHERAPY | 2023年 / 43卷 / 10期

关键词：

fluconazole; isavuconazole; itraconazole; pharmacodynamics; pharmacokinetics; posaconazole; voriconazole; EXPOSURE-RESPONSE RELATIONSHIP; INVASIVE FUNGAL-INFECTIONS; POSACONAZOLE TABLET; PHASE; 1B; VORICONAZOLE; SAFETY; GUIDELINES; RISK; PHARMACOKINETICS; ASPERGILLOSIS;

D O I：

10.1002/phar.2850

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Triazole antifungals (i.e., fluconazole, itraconazole, voriconazole, posaconazole, and isavuconazole) are commonly used in clinical practice to prevent or treat invasive fungal infections. Most triazole antifungals require therapeutic drug monitoring (TDM) due to highly variable pharmacokinetics, known drug interactions, and established relationships between exposure and response. On behalf of the Society of Infectious Diseases Pharmacists (SIDP), this insight describes the pharmacokinetic principles and pharmacodynamic targets of commonly used triazole antifungals and provides the rationale for utility of TDM within each agent.

引用

页码：1043 / 1050

页数：8

共 9 条

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